Evidence map›Paper›PMID 40855007›Full record

ArticleMolecular psychiatry2026

A single glucocorticoid response element regulates sociability in a sex-specific manner.

Brian F Corbett, Jay Arner, Sandra Luz, Jason Yan, Jose Castro-Vildosola, Tamara Hala, Deanne Taylor, Seema Bhatnagar

Abstract read
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian F CorbettCenter for Stress Neurobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jay ArnerCenter for Stress Neurobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sandra LuzCenter for Stress Neurobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jason YanCenter for Stress Neurobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jose Castro-VildosolaDepartment of Biology, Rutgers, The State University of New Jersey, Camden, NJ, USA.
Tamara HalaDepartment of Biology, Rutgers, The State University of New Jersey, Camden, NJ, USA.
Deanne TaylorDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3302-4610
Seema BhatnagarCenter for Stress Neurobiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. bhatnags@upenn.edu.

Funding

Training Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9M
NINDS NIH HHS T32 NS007413
6 · The paper itself

Abstract

Glucocorticoid receptors (GRs) regulate transcription to reduce inflammatory processes, modulate neuron function, and influence behavior. However, the precise loci bound by GRs that are critically important for these effects have not been fully determined. Here, we deleted the GR binding site near the sphingosine-1-phosphate receptor 3 (S1PR3) gene using a CRISPR/Cas9 approach in rats (S1PR3

Indexed as

Receptors, GlucocorticoidResponse ElementsSocial DefeatSphingosine-1-Phosphate ReceptorsAnimalsBinding SitesFemaleGlucocorticoidsLocus CoeruleusMaleNeuronsPrefrontal CortexRatsRats, Sprague-DawleySex FactorsSocial BehaviorGlucocorticoidsReceptors, GlucocorticoidS1PR3 protein, ratSphingosine-1-Phosphate Receptors

Identifiers

PMID40855007
PMCPMC12815654

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.