Evidence map›Paper›PMID 40854980›Full record

ArticleNPJ precision oncology2025

Systematic review and meta-analysis of artificial intelligence for image-based lung cancer classification and prognostic evaluation.

Xinyu Yuan, Heli Xu, Junkai Zhu, Zixuan Yang, Boyue Pan, Lin Wu, Huanhuan Chen

Abstract read
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  4. Review
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyu Yuan *Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Heli Xu *Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Junkai ZhuDepartment of Undergraduate, The First Affiliated Hospital of China Medical University, Shenyang, China.
Zixuan YangDepartment of Undergraduate, The First Affiliated Hospital of China Medical University, Shenyang, China.
Boyue PanDepartment of China Medical University, The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang, China.
Lin WuDepartment of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China. cmuwulin8681@163.com.
Huanhuan ChenDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China. 749509033@qq.com.

Funding

Doctoral Start-up Foundation of Liaoning Province No.2023-BS-092National Natural Science Foundation of China No.82304235
6 · The paper itself

Abstract

Lung cancer (LC) remains a leading global cause of cancer mortality, with current diagnostic and prognostic methods lacking precision. This meta-analysis evaluated the role of artificial intelligence (AI) in LC imaging-based diagnosis and prognostic prediction. We systematically reviewed 315 studies from major databases up to January 7, 2025. Among them, 209 studies on LC diagnosis yielded a combined sensitivity of 0.86 (0.84-0.87), specificity of 0.86 (0.84-0.87), and AUC of 0.92 (0.90-0.94). For LC prognosis, 106 studies were analyzed: 58 with diagnostic data showed a pooled sensitivity of 0.83 (0.81-0.86), specificity of 0.83 (0.80-0.86), and AUC of 0.90 (0.87-0.92). Additionally, 53 studies differentiated between low- and high-risk patients, with a pooled hazard ratio of 2.53 (2.22-2.89) for overall survival and 2.80 (2.42-3.23) for progression-free survival. Subgroup analyses revealed an acceptable performance. AI exhibits strong potential for LC management but requires prospective multicenter validation to address clinical implementation challenges.

Identifiers

PMID40854980
PMCPMC12378969

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.