Evidence map›Paper›PMID 40854968›Full record

ArticleInternational journal of obesity (2005)2025

Mortality risk associated with general and central obesity in inflammatory bowel disease patients: a long-term prospective cohort study.

Qian Zhang, Yutao Wang, Si Liu, Shengtao Zhu, Peng Li, Shutian Zhang, Zhirong Yang, Shanshan Wu

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qian Zhang *Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.
Yutao Wang *Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.ORCID http://orcid.org/0009-0008-6751-6219
Si LiuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.
Shengtao ZhuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.
Peng LiDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.
Shutian ZhangDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China.
Zhirong YangDepartment of Computational Biology and Medical Big Data, Faculty of Computer Science and Control Engineering, Shenzhen University of Advanced Technology, Shenzhen, China. zr.yang@siat.ac.cn.
Shanshan WuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory of Early Gastrointestinal Cancer Medicine and Medical Devices, Beijing, China. shanshanwu@ccmu.edu.cn.ORCID http://orcid.org/0000-0001-9791-8093

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo comprehensively investigate the long-term risk of all-cause mortality associated with general and central obesity in patients with inflammatory bowel disease (IBD).

methodsOverall, 5107 IBD patients [mean age 57.0 (SD: 8.0) years; 51.7% female] were included in the prospective cohort. General obesity was assessed using body mass index (BMI), while central obesity was evaluated using hip circumference, waist circumference (WC), waist-to-hip ratio (WHR), weight-adjusted waist index (WWI), conicity index (CI) and A Body Shape Index (ABSI). Primary outcome was all-cause death. Cox proportional hazards models were employed to examine the associations.

resultsDuring a median of 14.6 years' follow-up, 591 all-cause deaths occurred. At baseline, 1681(32.9%), 2229(43.6%), 1161(22.7%) and 36(0.70%) patients were BMI-defined normal, overweight, obesity and underweight. Underweight individuals had a 2.22-fold increased mortality risk than those with normal BMI (HR = 3.22, 95% CI:1.70-6.11), while null associations were observed for overweight or obesity. As for central obesity, individuals with the highest quartiles of WC (HR = 1.34, 1.02-1.76), WHR (HR = 1.56, 1.13-2.15), WWI (HR = 1.64, 1.24-2.16), CI (HR = 1.72, 1.28-2.30) and ABSI (HR = 1.64, 1.23-2.20) had a 34%, 56%, 64%, 72% and 64% greater mortality risk versus the lowest quartiles, with significant dose-response relationships (all P values < 0.05).

conclusionsCentral obesity and underweight, rather than general obesity, are associated with an increased risk of all-cause mortality in IBD patients. These findings underscore the importance of adequate nutrition and reduced visceral adiposity for long-term prognosis improvement of IBD patients.

Indexed as

Inflammatory Bowel DiseasesObesityObesity, AbdominalAdultAgedBody Mass IndexFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsWaist CircumferenceWaist-Hip Ratio

Identifiers

PMID40854968

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.