ArticleScientific reports2025
Study on differentially expressed genes and pattern recognition receptors in osteoporosis based on bioinformatics analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Identification of potential biomarkers related to the Bitong mixture in osteoarthritis based on bioinformatics and network pharmacology, and exploration of the mechanism involved.Frontiers in immunology · 2026Article
- Upregulated haptoglobin in classical monocytes serves as a diagnostic and immunological biomarker in myocardial infarction: a cross-sectional multi-omics study.Frontiers in immunology · 2025Article
- Exploring the mechanism of Heidihuang Pill in the treatment of osteoporosis based on network pharmacology, molecular docking, and experimental validation.Frontiers in endocrinology · 2025Article
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Authors and funding
7 authors.
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Abstract
Osteoporosis is a common skeletal disorder characterized by low bone mass and structural deterioration, leading to an increased risk of fractures. This study aimed to explore the molecular mechanisms underlying osteoporosis using bioinformatics approaches, with a focus on pattern recognition receptor-related differentially expressed genes (PRR-related DEGs). Two gene expression datasets (GSE7429 and GSE56815) were retrieved from the GEO database, comprising 30 osteoporosis samples and 30 matched controls. Data integration and batch effect correction were performed using the GEOquery and sva packages, followed by differential expression analysis with limma. A total of 1,052 pattern recognition receptor-related genes (PRR-related genes) were obtained from GeneCards, and 98 PRR-related DEGs were identified. GO and KEGG enrichment analyses revealed that these genes are primarily involved in the MAPK cascade, calcium ion homeostasis, leukocyte migration, and the regulation of inflammatory responses. A protein-protein interaction (PPI) network was constructed using STRING, and six hub genes (MDM2, AKT1, ESR1, NCOR1, CCND1, and NCOA2) were identified via CytoHubba. Regulatory networks involving miRNAs and transcription factors were constructed using ENCORI and ChIPBase. ROC curve analysis showed that ESR1 exhibited moderate diagnostic potential (AUC > 0.7). In conclusion, this study systematically identifies PRR-related DEGs and hub genes associated with osteoporosis through integrated bioinformatics analysis. These findings may contribute to a better understanding of immune-related molecular mechanisms and lay the groundwork for future research on potential diagnostic markers or therapeutic strategies.
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