Obesity drives temporally distinct physical activity disruptions in mice under a fixed 24-h light-dark cycle.

Abigail Usiyevich, Yufan Li, Reema Sharma, Kenny Arbuckle, Jay Shah, Bridget A Matikainen-Ankney

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Abigail UsiyevichBehavioral and Systems Neuroscience, Psychology Department, Rutgers University, Busch Campus Psychology Building Room 317, 152 Frelinghuysen Road, Piscataway, NJ, 08854, USA.

Yufan LiBehavioral and Systems Neuroscience, Psychology Department, Rutgers University, Busch Campus Psychology Building Room 317, 152 Frelinghuysen Road, Piscataway, NJ, 08854, USA.

Reema SharmaBehavioral and Systems Neuroscience, Psychology Department, Rutgers University, Busch Campus Psychology Building Room 317, 152 Frelinghuysen Road, Piscataway, NJ, 08854, USA.

Kenny ArbuckleBehavioral and Systems Neuroscience, Psychology Department, Rutgers University, Busch Campus Psychology Building Room 317, 152 Frelinghuysen Road, Piscataway, NJ, 08854, USA.

Jay ShahBehavioral and Systems Neuroscience, Psychology Department, Rutgers University, Busch Campus Psychology Building Room 317, 152 Frelinghuysen Road, Piscataway, NJ, 08854, USA.

Bridget A Matikainen-AnkneyBehavioral and Systems Neuroscience, Psychology Department, Rutgers University, Busch Campus Psychology Building Room 317, 152 Frelinghuysen Road, Piscataway, NJ, 08854, USA. bridget.m@rutgers.edu.

Funding

Defining the neural basis for persistent obesityK01DK134804 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI MATIKAINEN-ANKNEY, BRIDGET · 2023 to 2025

$456k

NIDDK NIH HHS DK134804NIDDK NIH HHS K01 DK134804

6 · The paper itself

Abstract

24-h cycles regulate activity and feeding behavior, and obesity and metabolic dysfunction may disrupt such rhythms. Here, using a fixed 24-h light-dark cycle, we investigate sex-specific diurnal physical activity patterns in obese and normal weight mice. We observe that feeding behavior aligns with a mid-dark cycle activity peak. Using passive home cage monitoring and operant feeding tasks, we demonstrate that male and female mice exhibit distinct temporal activity profiles, particularly during the late dark cycle. Diet-induced obesity selectively suppressed mid-dark cycle activity, a temporal window linked to peak food-seeking behavior. These findings highlight temporal disruptions to physical activity in a rodent model of diet-induced obesity and offer insights into potential interactions between feeding behavior and 24 physical activity patterns.

Indexed as

Circadian RhythmObesityPhotoperiodPhysical Conditioning, AnimalAnimalsDisease Models, AnimalFeeding BehaviorFemaleMaleMiceMice, Inbred C57BLFeeding behaviorObesityPhysical activitySex differences

Identifiers

PMID40854958

DOI10.1038/s41598-025-16084-4

PMCPMC12379191

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.