Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Kayleigh M VoosDepartment of Cell and Developmental Biology, Perelman School of Medicine. University of Pennsylvania, Philadelphia, PA, USA.
Joyce TzengDepartment of Cell and Developmental Biology, Perelman School of Medicine. University of Pennsylvania, Philadelphia, PA, USA.
Priya PatelDepartment of Cell and Developmental Biology, Perelman School of Medicine. University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0007-5572-1170
Sophie RubinskyDepartment of Cell and Developmental Biology, Perelman School of Medicine. University of Pennsylvania, Philadelphia, PA, USA.
Ha E ChoiDepartment of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0009-0000-3990-1146
Trevor PharrDepartment of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sebastian SookramDepartment of Cell and Developmental Biology, Perelman School of Medicine. University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0005-1966-1639
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine. University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8262-6549
Erik J SoderblomDepartment of Cell Biology, Duke University School of Medicine, Duke University, Durham, NC, USA.
Damaris N LorenzoDepartment of Cell and Developmental Biology, Perelman School of Medicine. University of Pennsylvania, Philadelphia, PA, USA. damaris.lorenzo@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-6856-2988
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Pilot & Feasibility ProgramP30DK124723 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI P Darrell Neufer · 2020 to 2026
$11.0M
Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL · 2013 to 2019
$8.0M
Targeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1M
Understanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failureR01HL165792 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2022 to 2025
$2.7M
Elucidating the synaptic interactome of the high risk autism gene ANK2R01MH127848 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Damaris N Lorenzo · 2022 to 2026
$2.2M
Role of Ankyrin-B in the Nervous SystemR01NS110810 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LORENZO, DAMARIS N · 2020 to 2024
$1.9M
Training in Mechanistic, Interdisciplinary Studies of Biological SystemsT32GM119999 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAMSDEN, DALE A · 2017 to 2021
$1.2M
Indirect calorimetry cages equipped for glucose and blood pressure telemetryS10OD025098 · OD · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2019 to 2019
$750k
A mechanism of skeletal muscle ER-mitochondria interaction and bioenergetics modulationF31DK132982 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VOOS, KAYLEIGH MARIE · 2022 to 2024
$104k
American Diabetes Association (ADA) 1-19-JDF-081NHLBI NIH HHS R01 HL165792NIAMS NIH HHS P30 AR069619NICHD NIH HHS U54 HD079124NIDDK NIH HHS F31 DK132982NIDDK NIH HHS P30 DK019525NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK124723NIDDK NIH HHS R01 DK098656NIGMS NIH HHS T32 GM119999NIH HHS S10 OD025098NIMH NIH HHS R01 MH127848NINDS NIH HHS R01 NS110810U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK098656U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HL165792U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH127848U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01NS110810
6 · The paper itself
Abstract
Mitochondrial dynamics enable cellular adaptation to fluctuations in energy demand, such as those imposed on skeletal muscle by exercise, metabolic disorders, or aging. Here, we report a novel pathway that modulates mitochondria dynamics in skeletal muscle involving the scaffolding protein ankyrin-B. Rare variants in ankyrin-B, encoded by ANK2, increase risk for cardio-metabolic syndrome in humans and mice. We show that mice selectively lacking skeletal muscle ankyrin-B have reduced endurance exercise capacity without alterations in muscle strength or systemic glucose regulation. Muscle fibers in these mice have increased oxidative stress, reduced fatty acid oxidation, and enlarged and hyperconnected mitochondria. We found that ankyrin-B interacts with and is required for efficient mitochondria recruitment of fission modulators and sarcoplasmic reticulum-mitochondria coupling. Thus, we conclude that ankyrin-B enables substrate adaptability and bioenergetic homeostasis under energetic stress, and exercise capacity by promoting efficient mitochondrial fission in skeletal muscle.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity. · full record | OpenQuestion