Evidence map›Paper›PMID 40854843›Full record

ArticleBMJ open2025

Machine-learning-based artificial intelligence tools for the diagnosis of tropical fevers: a systematic review and meta-analysis protocol of diagnostic test accuracy.

Shravya Chitrapady, Rajalakshmi Rajendran, Haritha K, Tejashree M U, Muhammed Rashid, Pooja Gopal Poojari, Vijayanarayana K, Muralidhar Varma, Vasudha Devi, Dinesh Acharya and 2 more

Abstract read
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Global Genomic Surveillance.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shravya ChitrapadyDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Rajalakshmi RajendranDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Haritha KDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Tejashree M UDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Muhammed RashidDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Pooja Gopal PoojariDepartment of Pharmacy Practice, Srinivas College of Pharmacy, Mangaluru, Karnataka, India.
Vijayanarayana KDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Muralidhar VarmaDepartment of Infectious Disease, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Vasudha DeviDepartment of Pharmacology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Dinesh AcharyaDepartment of Computer Science and Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Sohil KhanPharmacotherapeutics and Evidence Based Practice, Griffith University School of Pharmacy and Medical Sciences, Gold Coast, Queensland, Australia.
Girish ThungaDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India girish.thunga@manipal.edu.ORCID http://orcid.org/0000-0003-1257-969X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRecent advancements in diagnosing tropical fevers increasingly use artificial intelligence (AI). These innovations focus on diagnosing single or multiple diseases, significantly reducing the global burden of tropical fevers. This protocol helps to identify the key factors required for a systematic review of AI-based machine learning (ML) diagnostic test accuracy-based studies to obtain a view on the pooled performance of different types of available tools. This systematic review protocol aims to review the type of ML-based AI tools and pool the performance metrics of the currently available ML-based AI devices. METHODS AND ANALYSIS: Patients with tropical fevers will be recruited, whereas the ML-based AI model will be the index test, and dengue, scrub typhus, leptospirosis, malaria, influenza, typhoid, chikungunya and Japanese encephalitis will be the target conditions considered for the review. Search does not restrict to any time period, and all original research studies with cross-sectional study design that are related to the development of ML tools or specific algorithms used for the diagnosis of tropical fevers from the date of inception until the date will be considered for review.Specific keywords and relevant MeSH terms for 'artificial intelligence', 'diagnosis, and 'tropical fevers' will be selected. A systematic search will be conducted in Medline/PubMed, Embase, Cochrane and Scopus covering literature from inception to February 2025. Upon retrieval of all the studies into an Excel sheet, deduplication will be done, followed by initial and secondary screening. Data extraction will be conducted using Microsoft Excel. The obtained data will be summarised narratively, and a meta-analysis of quantitative data will be performed using Meta-Disc software. The Quality Assessment of Diagnostic Accuracy Studies 2 tool will be employed to evaluate the quality of the studies. The study is planned to start in March 2025 and will be completed by September 2025. ETHICS AND DISSEMINATION: Ethical approval is not required for this systematic review and meta-analysis, as it will use data from previously published studies. The results of the review will be published in academic journals and presented at international conferences. PROSPERO REGISTRATION NUMBER: CRD42024516128.

Indexed as

Artificial IntelligenceDiagnostic Tests, RoutineFeverMachine LearningDengueHumansMeta-Analysis as TopicResearch DesignSystematic Reviews as TopicTropical MedicineArtificial IntelligenceNeglected DiseasesSystematic Review

Identifiers

PMID40854843
PMCPMC12382579

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.