Evidence map›Paper›PMID 40854835›Full record

ArticleBMJ open2025

Randomised controlled trial of a low plastic diet and lifestyle intervention for adults with cardiometabolic risk factors: the Plastic Exposure Reduction Transforms Health (PERTH) trial - a protocol.

Andrew Lucas, Amelia Harray, Lelinh Duong, Susan Herrmann, Philip Vlaskovsky, Michelle Trevenen, Dick Chan, Hannah Papendorf, Tony Smith, Lilith Flint and 10 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06571994 (Examining the Effect of Minimal Plastics Exposure on Plastic-Associated Chemicals), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06571994 nacompletednot on this map

Examining the Effect of Minimal Plastics Exposure on Plastic-Associated Chemicals (PAC) Excretion and Biomarkers in Adults With Cardiometabolic Risk Factors

TypeinterventionalSponsorThe University of Western AustraliaRan2024 to 2025Enrolled60ConditionsEndocrine Disruptors, Inflammation, Cardiometabolic Risk FactorsArmsLow Plastic Intervention
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Dietitians as Connectors and Brokers in Food Systems Transformation: A Reflexive Perspective From a Regional Circularity Case Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Andrew Lucas *School of Biomedical Sciences, The University of Western Australia, Nedlands, Western Australia, Australia.
Amelia Harray *Medical School, The University of Western Australia, Nedlands, Western Australia, Australia.
Lelinh DuongMedical School, The University of Western Australia, Nedlands, Western Australia, Australia.ORCID http://orcid.org/0000-0001-9709-6958
Susan HerrmannMedical School, The University of Western Australia, Nedlands, Western Australia, Australia.
Philip VlaskovskyCentre for Applied Statistics, The University of Western Australia, Perth, Western Australia, Australia.
Michelle TrevenenCentre for Applied Statistics, The University of Western Australia, Perth, Western Australia, Australia.
Dick ChanMedical School, The University of Western Australia, Nedlands, Western Australia, Australia.
Hannah PapendorfMedical School, The University of Western Australia, Nedlands, Western Australia, Australia.
Tony SmithMedical School, The University of Western Australia, Nedlands, Western Australia, Australia.
Lilith FlintDepartment of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria, Australia.
Alex LiuMedical School, The University of Western Australia, Nedlands, Western Australia, Australia.
Silvana GaudieriSchool of Human Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Xianyu WangMinderoo Centre - Plastics and Human Health, The University of Queensland, Woolloongabba, Queensland, Australia.
Jochen F MuellerMinderoo Centre - Plastics and Human Health, The University of Queensland, Woolloongabba, Queensland, Australia.
Kevin V ThomasMinderoo Centre - Plastics and Human Health, The University of Queensland, Woolloongabba, Queensland, Australia.
Kevin MurrayCentre for Applied Statistics, The University of Western Australia, Perth, Western Australia, Australia.ORCID http://orcid.org/0000-0002-8856-6046
Christos SymeonidesMinderoo Foundation, Perth, Western Australia, Australia.
Sarah DunlopMinderoo Foundation, Perth, Western Australia, Australia.
Gerald WattsMedical School, The University of Western Australia, Nedlands, Western Australia, Australia.
Michaela LucasMedical School, The University of Western Australia, Nedlands, Western Australia, Australia michaela.lucas@health.wa.gov.au.ORCID http://orcid.org/0000-0001-8881-9990

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPhthalates and bisphenols, chemicals commonly used in the production of plastic products, exhibit endocrine disrupting properties linked to obesity and systemic inflammation. Given the ubiquitous use of plastic chemicals, their adverse impact on human health is of great importance. In this protocol, we describe a randomised controlled trial aimed at testing whether minimising exposure to plastics and plastic-associated chemicals (PACs) in community-dwelling adults with cardiometabolic risk factors can reduce urinary excretion of PACs and improve cardiometabolic health. METHODS AND ANALYSIS: The study will recruit (n=60) community-dwelling adults (18-60 years) with cardiometabolic risk factors, characterised by a body mass index of ≥30 kg/m ETHICS AND DISSEMINATION: The PERTH Trial has ethics approval from the University of Western Australia Human Research Ethics Committee; 2021-ET001118. Results will be submitted for publication in peer-reviewed journals and presented at conferences. TRIAL REGISTRATION NUMBER: NCT06571994.

Indexed as

Cardiometabolic Risk FactorsCardiovascular DiseasesDietEnvironmental ExposureLife StylePlasticsAdolescentAdultBenzhydryl CompoundsEndocrine DisruptorsFemaleHumansMaleMiddle AgedPhenolsPhthalic AcidsBenzhydryl CompoundsEndocrine DisruptorsPhenolsphthalic acidPhthalic AcidsPlasticsCardiovascular DiseaseClinical TrialNUTRITION & DIETETICSObesityPUBLIC HEALTHRandomized Controlled Trial

Identifiers

PMID40854835
PMCPMC12382529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.