Evidence map›Paper›PMID 40854816›Full record

ArticleJournal for immunotherapy of cancer2025

Neoadjuvant PD-1 blockade: a new treatment option for patients with early-stage mismatch repair deficient solid tumors.

Kristin G Anderson, Antoni Ribas

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kristin G AndersonMicrobiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA abv9kn@virginia.edu.ORCID http://orcid.org/0000-0001-9263-4438
Antoni RibasUniversity of California Los Angeles, Los Angeles, California, USA.ORCID http://orcid.org/0000-0003-3669-8458

Funding

Project 3: Modeling and overcoming resistance to melanoma immunotherapyP01CA244118 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORICEAU, GATIEN P · 2020 to 2024
$12.8M
Next Generation Cancer Immunotherapies to Defeat MelanomaR35CA197633 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTONI RIBAS · 2015 to 2026
$10.4M
Engineering T cells to overcome inhibitory receptor signals that limit the efficacy of adoptive cell therapy against ovarian cancerK22CA266737 · NCI · UNIVERSITY OF VIRGINIA · PI ANDERSON, KRISTIN GAIL · 2023 to 2025
$566k
NCI NIH HHS K22 CA266737NCI NIH HHS P01 CA244118NCI NIH HHS R35 CA197633
6 · The paper itself

Abstract

DNA mismatch repair deficiency has been identified as a biomarker that strongly correlates with tumor response to anti-programmed cell death protein-1 (PD-1) checkpoint blockade therapy in the metastatic setting. In a promising Phase 2 study published in the

Indexed as

DNA Mismatch RepairImmune Checkpoint InhibitorsNeoadjuvant TherapyNeoplasmsProgrammed Cell Death 1 ReceptorHumansNeoplasm StagingImmune Checkpoint InhibitorsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorBiomarkerCirculating tumor DNA - ctDNAColorectal CancerImmune Checkpoint InhibitorMismatch repair - MMR

Identifiers

PMID40854816
PMCPMC12382506

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.