Evidence map›Paper›PMID 40854807›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2025

Association of Area Deprivation Index with perinatal and COVID-19 outcomes during the early pandemic: a secondary analysis of a prospective cohort study.

Abigail Bell, Megan Foeller, Candice Woolfolk, Emily Diveley, Fan Zhang, Amy Scheffer, Ruizhi Huang, Daniel Jackson, Nandini Raghuraman, Ebony Carter and 2 more

Abstract read
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abigail BellDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Megan FoellerDepartment of Obstetrics and Gynaecology, St Alphonsus Regional Medical Center, Boise, ID, USA.
Candice WoolfolkDivision of OB/GYN Clinical Research, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Emily DiveleyDivision of OB/GYN Clinical Research, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Fan ZhangDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Amy SchefferDivision of OB/GYN Clinical Research, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Ruizhi HuangDivision of Maternal-Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Daniel JacksonMercy Clinic Maternal and Fetal Medicine, St. Louis, MO, USA.
Nandini RaghuramanDivision of Maternal-Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Ebony CarterDivision of Maternal-Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Indira U MysorekarDivision of Maternal-Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.
Jeannie C KellyDivision of Maternal-Fetal Medicine and Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.

Funding

Safety, Testing/Transmission, and Outcomes in Pregnancy with COVID-19 (STOP-COVID-19 study)R01HD091218 · NICHD · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, MYSOREKAR, INDIRA U · 2017 to 2022
$4.1M
The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta Project (OPIOID BPP)R01HD113199 · NICHD · WASHINGTON UNIVERSITY · PI Jeannie Chen Kelly, Yong Wang · 2023 to 2026
$3.1M
NICHD NIH HHS R01 HD091218NICHD NIH HHS R01 HD113199
6 · The paper itself

Abstract

objectiveWe sought to evaluate the relationship between neighborhood-level deprivation and perinatal outcomes, particularly preterm birth, as well as COVID-19 outcomes among pregnant patients during the early pandemic.

methodsWe performed a secondary analysis of a prospective longitudinal cohort study that investigated the impact of prenatal COVID-19 exposure on perinatal outcomes. Pregnant patients were recruited 12/23/20-7/18/22 and serially assessed for COVID-19 exposure during pregnancy, with serum antibody testing, electronic medical record review, and patient report. For this secondary analysis, address at the time of delivery was used to categorize patients into low ADI (≤50

results306 patients were included: 124 in the low ADI group and 182 in the highest ADI group. Baseline characteristics differed between groups, including notably lower rates of COVID-19 vaccination in the highest ADI group (24.2% vs 54.0%,

conclusionPatients in the highest ADI group, therefore living in the most deprived neighborhoods, were more likely to experience extremely preterm birth, contract SARS-CoV-2 infection, and become hospitalized due to COVID-19. The interplay of social determinants of health and perinatal outcomes must be better studied to target interventions to modifiable risk factors.

Indexed as

COVID-19Pregnancy Complications, InfectiousPregnancy OutcomePremature BirthAdultFemaleHumansInfant, NewbornLongitudinal StudiesPregnancyProspective StudiesSARS-CoV-2Area Deprivation IndexCOVID-19Neighborhood deprivationpreterm birthsocial determinants of health

Identifiers

PMID40854807
PMCPMC12593223

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.