ArticleAJNR. American journal of neuroradiology2026
Measures of Brain Metabolism and Diffusion in Neonates of Mothers with Diabetes.
Article in AJNR. American journal of neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
background and purposeMaternal diabetes may affect neonates' long-term neurodevelopment and cognitive behavior. Brain biochemistry and white matter fiber tracts may reveal early changes of brain abnormality. The purpose of this study was to compare brain metabolites and fiber structures in infants of mothers with diabetes with those of mothers without diabetes during the early stage of neonatal neurodevelopment. MATERIALS AND
methodsPregnant women with diabetes mellitus (DM) and healthy controls were recruited prospectively. Baseline characteristics including maternal and gestational age, weight, height, body mass index (BMI), and types of diabetes were extracted from the mothers and neonates in the clinical record. Infants of mothers with diabetes and healthy controls underwent scans by using a 3T MRI scanner. T2-weighted anatomic images were acquired for voxel positioning.
resultsMRI data were successfully obtained from 77 neonates (41 healthy controls and 36 infants of mothers with diabetes). Gestational diabetes was the most common diagnosis (53%), followed by type 2 (33%) and type 1 pregestational DM (14%). Weight (
conclusionsThe increase of myo-inositol in infants of mothers with diabetes may reflect a compensatory mechanism related to altered blood glucose to preserve and promote β-cell growth to enhance the production of insulin. The increase in mean diffusivity is consistent with decreased water diffusion, which potentially reflects abnormal changes in myelination and axonal loss.
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