Evidence map›Paper›PMID 40854646›Full record

ReviewJournal, genetic engineering & biotechnology2025

Plant-based edible vaccines: Can cholera be the case study in Africa?

Beenzu Siamalube, Emmanuel Ehinmitan, Lupupa Kachenga, Steven Runo, Maina Ngotho, Justus Onguso

Abstract readReview
In one paragraph

Review in Journal, genetic engineering & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beenzu SiamalubeDepartment of Molecular Biology and Biotechnology, Pan African University Institute for Basic Sciences, Technology and Innovation, Nairobi, Kenya. Electronic address: siamalube.beenzu@students.jkuat.ac.ke.
Emmanuel EhinmitanDepartment of Molecular Biology and Biotechnology, Pan African University Institute for Basic Sciences, Technology and Innovation, Nairobi, Kenya.
Lupupa KachengaSchool of Natural Sciences, Eden University, Lusaka, Zambia.
Steven RunoDepartment of Animal Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Maina NgothoDepartment of Biochemistry, Microbiology and Biotechnology, Kenyatta University, Nairobi, Kenya.
Justus OngusoInstitute for Biotechnology Research, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines are employed as a sanitary approach that is implemented to lessen the hurdles caused by infectious diseases on the safety of public health. A vaccine is biologically made from inactive components of microbes, to enhance immunity and as a defense mechanism adverse to parasitic, bacterial and viral illnesses. Nonetheless, the mode of production that involves purification is quite costly, more so, to low and middle-income countries, especially in Africa. Conventional oral cholera vaccines, though commercially available, face logistical challenges to be transported and distributed to target populations such as Africa. Edible vaccines derived from plants, on the other hand, offer cost-effective and bio-friendly production cost, they are easily administered to all age groups and can be grown near-user-site. This article thoroughly assesses the capability of plant-based edible vaccines as an option for immunization against cholera with exclusive concentration on the African continent.

Indexed as

AfricaEdible cholera vaccinesGenetic modificationImmunizationInfectious diseasesPlant biotechnology

Identifiers

PMID40854646
PMCPMC12240092

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.