Evidence map›Paper›PMID 40854635›Full record

ArticleJournal, genetic engineering & biotechnology2025

Phytochemical screening, antioxidant, and antimicrobial analysis of Portulaca oleracea seeds with in-silico molecular docking insights.

Khursheed Ahmad Sheikh, Reyaz Hassan Mir, Mohammad Ovais Dar, Adil Farooq Wali, Insha Qadir, Sheeba Nazir, Mohammed Iqbal Zargar, Sirajunisa Talath, Sathvik B Sridhar, Javedh Shareef and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal, genetic engineering & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Frontiers in nutrition · 2026
    Article
  5. From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases.Advances in pharmacological and pharmaceutical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Khursheed Ahmad SheikhPharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar 190006 Kashmir, India; Pharmaceutical Chemistry, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Reyaz Hassan MirPharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar 190006 Kashmir, India. Electronic address: reyazhassan249@gmail.com.
Mohammad Ovais DarDepartment of Pharmaceutical Chemistry, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana 133207, India.
Adil Farooq WaliDepartment of Pharmaceutical Chemistry, RAK College of Pharmacy, RAK Medical and Health Science University, Ras Al Khaimah, United Arab Emirates.
Insha QadirPharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar 190006 Kashmir, India.
Sheeba NazirPharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar 190006 Kashmir, India.
Mohammed Iqbal ZargarPharmaceutical Biotechnology Division Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar 190006, India.
Sirajunisa TalathDepartment of Pharmaceutical Chemistry, RAK College of Pharmacy, RAK Medical and Health Science University, Ras Al Khaimah, United Arab Emirates.
Sathvik B SridharDepartment of Clinical Pharmacy & Pharmacology, RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.
Javedh ShareefDepartment of Clinical Pharmacy & Pharmacology, RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.
Mubashir Hussain MasoodiPharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Hazratbal, Srinagar 190006 Kashmir, India. Electronic address: mubashir@kashmiruniversity.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPortulaca oleracea (PO), an annual succulent herb with global distribution, has been used medicinally since ancient times, earning the title "global panacea."

aimThis study aimed to perform phytochemical screening, antioxidant and antimicrobial analysis of PO seeds, including GCMS analysis of methanolic extract and molecular docking for antimicrobial mechanisms. MATERIALS AND

methodsPO seeds underwent phytochemical screening and methanolic extract analysis via DPPH, NO radical scavenging, and reducing power assays. Antimicrobial activity was tested against bacteria and fungi, with GCMS identifying compounds. Molecular docking was conducted via Autodock vina, against targets beta-tubulin (5FNV) and ABC transporter (6J9W).

resultsMethanolic extract showed strong antioxidant activity (IC

conclusionThe methanolic extract's potent antioxidant and antimicrobial effects, supported by colchicine's binding affinity, validate PO's medicinal potential, suggesting further therapeutic exploration.

Indexed as

AntibacterialAntifungal antimicrobialAntioxidantDPPHDrug discoveryNatural compoundsPortulaca oleraceaPurslaneTotal flavonoid contentTotal phenolic content

Identifiers

PMID40854635
PMCPMC12219364

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.