Evidence map›Paper›PMID 40854568›Full record

ArticleNephrology (Carlton, Vic.)2025

Clinical Outcomes of a Dedicated Kidney Adolescent and Young Adult Clinic (KAYAC) in South Africa.

Zibya Barday, Nicola Wearne, Erika S W Jones, Mignon McCulloch, Jacqueline Hoare, Kathryn Manning, Suzanne Pretorius, Bianca J Davidson

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zibya BardayNephrology and Hypertension, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0009-0002-5053-5495
Nicola WearneNephrology and Hypertension, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Erika S W JonesNephrology and Hypertension, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Mignon McCullochPaediatrics, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Jacqueline HoarePsychiatry and Mental Health Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Kathryn ManningNephrology and Hypertension, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Suzanne PretoriusNephrology and Hypertension, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Bianca J DavidsonNephrology and Hypertension, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-6974-8581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimAdolescents and young adults (AYAs) are increasingly utilising kidney health care services. However, there is no data on the impact of kidney transition clinics, as well as the AYA spectrum of kidney diseases, in South Africa (SA). This study evaluates kidney outcomes and patient survival amongst AYA patients attending a dedicated kidney AYA clinic (KAYAC).

methodsThis 5-year retrospective study included AYA (aged 13-25) with kidney disease, attending a tertiary nephrology service. A comparative analysis of outcomes between patients who attended the KAYAC and those attending the standard-of-care adult kidney clinics was performed. The primary composite outcome assessed included doubling of creatinine, reduction in eGFR > 40%, kidney failure, requirement for kidney replacement therapy, or death. Logistic regression evaluated the associations between relevant variables, death, and loss to follow-up (LTFU).

resultsThe AYA cohort consisted of 292 patients: 111 (38.0%) attended KAYAC and 181 (62.0%) attended adult clinics. Glomerular diseases (72.6%), congenital urinary tract anomalies (10.6%) and hereditary conditions (8.2%) were the most common causes of kidney disease. The KAYAC group had delayed progression to kidney failure with an improved composite outcome (p = 0.018), lower mortality (p = 0.046) and less LTFU (p = 0.001). Both groups demonstrated high rates of non-adherence, with a prevalence of 33.9% in the total cohort.

conclusionAYA are a unique population who could benefit from KAYAC transition clinics. A dedicated KAYAC has been found to be associated with better kidney outcomes, lower mortality and less LTFU, underscoring its critical role in resource-limited settings.

Indexed as

Ambulatory Care FacilitiesKidney DiseasesTransition to Adult CareAdolescentAdultFemaleGlomerular Filtration RateHumansMaleRenal Replacement TherapyRetrospective StudiesSouth AfricaTime FactorsTreatment OutcomeYoung AdultAdolescent and young adultchronic kidney diseasekidney outcomestransition clinic

Identifiers

PMID40854568
PMCPMC12377949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.