Evidence map›Paper›PMID 40854445›Full record

ArticleFree radical biology & medicine2025

Redox reactivities of membrane-bound amyloid-β-Cu complexes and their targeting by metallothionein-3.

Luciano Perez-Medina, Gabriele Meloni

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Luciano Perez-MedinaDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, 75080, USA.
Gabriele MeloniDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, 75080, USA. Electronic address: gabriele.meloni@utdallas.edu.

Funding

Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteinsR35GM128704 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Gabriele Meloni · 2018 to 2026
$3.5M
Drug Interactions and Bioavailability of CranberryR21AT002073 · NCCIH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DONOVAN, JENNIFER L · 2004 to 2005
$495k
Effects of dietary agents on lysosomes in mucolipidosisR21AT001935 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI VASSILEV, PETER M · 2004 to 2005
$425k
NCCIH NIH HHS R21 AT001935NCCIH NIH HHS R21 AT002073NIGMS NIH HHS R35 GM128704
6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCopperMetallothioneinMetallothionein 3Nerve Tissue ProteinsPeptide FragmentsCell MembraneHumansLipid BilayersLipid PeroxidationOxidation-ReductionReactive Oxygen SpeciesAmyloid beta-Peptidesamyloid beta-protein (1-42)CopperLipid BilayersMetallothioneinMetallothionein 3Nerve Tissue ProteinsPeptide FragmentsReactive Oxygen SpeciesAlzheimer's diseaseAmyloid-betaCell membraneCopperDi-tyrosineHydroxyl radicalLipid peroxidationMalondialdehydeMetallothionein-3Reactive oxygen species

Identifiers

PMID40854445
PMCPMC12542617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.