ArticleBioorganic & medicinal chemistry letters2025
Solid-phase synthesis of a pyrrole library and identification of bioactive compounds.
Article in Bioorganic & medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pyrrole derivatives represent a privileged scaffold in medicinal chemistry due to their frequent presence in biologically active compounds. Herein, we report the solid-phase synthesis of a combinatorial library consisting of 211 pyrrole derivatives using a split-and-pool strategy based on the Hantzsch pyrrole synthesis. The pooled compounds were evaluated in a cell proliferation assay using the human lymphoblastoid cell line P493-6, a model with Myc-regulated growth. Four pools exhibited notable inhibitory activity, and subsequent deconvolution and synthesis of 16 individual pyrrole derivatives led to the identification of several compounds with potent antiproliferative profiles.
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