Evidence map›Paper›PMID 40854136›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

De novo rates of a

Daniel Melamed, Revital Shemer, Evgeni Bolotin, Michael B Yakass, Dorit Fink-Barkai, Edem K Hiadzi, Karl L Skorecki, Adi Livnat

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Evolution expresses the second law of thermodynamics in action.Journal of the Royal Society, Interface · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel MelamedDepartment of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.
Revital ShemerThe Ruth and Bruce Rappaport Faculty of Medicine & Research Institute, Technion-Israel Institute of Technology, Haifa 3525433, Israel.ORCID 0009-0008-2242-7968
Evgeni BolotinDepartment of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0001-6581-3262
Michael B YakassDepartment of Biochemistry, Cell and Molecular Biology, West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon 00233, Accra, Ghana.ORCID 0000-0002-6903-0633
Dorit Fink-BarkaiDepartment of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.
Edem K HiadziAssisted Conception Unit, Lister Hospital & Fertility Centre, Accra CT966, Ghana.
Karl L SkoreckiThe Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.ORCID 0000-0002-0900-3406
Adi LivnatDepartment of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0001-7304-8871

Funding

Israel Science Foundation (ISF) 3757/20John Templeton Foundation (JTF) 61129John Templeton Foundation (JTF) 62220
6 · The paper itself

Abstract

Mutation rates have long been measured as averages across many genomic positions. Recently, a method to measure the rates of individual mutations was applied to a narrow region in the human hemoglobin subunit beta (

Indexed as

Black PeopleMutation RateTrypanosoma brucei gambienseTrypanosomiasis, AfricanWhite PeopleApolipoprotein L1European PeopleHemoglobin, SickleHumansMaleMutationSub-Saharan African PeopleAPOL1 protein, humanApolipoprotein L1Hemoglobin, SickleAPOL1 G1 allelede novo mutation rateshuman African sleeping sicknessmaximum depth sequencingnonrandom mutation

Identifiers

PMID40854136
PMCPMC12415191

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.