Evidence map›Paper›PMID 40854017›Full record

ArticleCirculation2025

Investigating the Risk of Arrhythmogenesis Associated With Fentanyl Abuse Using Human and Mouse Cardiomyocytes.

Gema Mondéjar-Parreño, Shane Rui Zhao, Xu Cao, Yu Liu, Johnson Y Yang, James W S Jahng, Jeremy Leitz, David Wu, Nazish Sayed, José Jalife and 1 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gema Mondéjar-ParreñoStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).ORCID 0000-0001-9514-8961
Shane Rui ZhaoStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).ORCID 0000-0002-2137-5536
Xu CaoStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).ORCID 0000-0002-8368-6727
Yu LiuStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).ORCID 0000-0001-7110-127X
Johnson Y YangStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).
James W S JahngStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).ORCID 0000-0003-2367-6567
Jeremy LeitzDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine (J.L.).ORCID 0009-0009-9976-2497
David WuStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).ORCID 0000-0002-1193-8307
Nazish SayedStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).ORCID 0000-0002-8229-721X
José JalifeCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (G.-M.P., J.J.).ORCID 0000-0003-0080-3500
Joseph C WuStanford Cardiovascular Institute (G.M.-P., S.R.Z., X.C., Y.L., J.Y.Y., J.W.S.J., D.W., N.S., J.C.W.).ORCID 0000-0002-6068-8041

Funding

Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCsR01HL130020 · NHLBI · STANFORD UNIVERSITY · PI Ronglih Liao, MARK MERCOLA · 2016 to 2026
$7.3M
Human Induced Pluripotent Stem Cells for Cardiovascular Disease ModelingR01HL113006 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2012 to 2025
$6.8M
Single Cell Sequencing of Human iPSC-CM Subtype Identity and FunctionR01HL145676 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Joseph C. Wu · 2019 to 2026
$5.1M
Human iPSC Model to Elucidate Metabolic Interplay in Diabetic CardimyopathyR01HL146690 · NHLBI · STANFORD UNIVERSITY · PI LIAO, RONGLIH, MERCOLA, MARK · 2019 to 2025
$5.1M
Elucidating ECM Signaling in Cardiac Organoids with Machine Learning and Single-cell MultiomicsR01HL163680 · NHLBI · STANFORD UNIVERSITY · PI RAJADAS, JAYAKUMAR, WONG, WING H. · 2022 to 2025
$2.5M
Peptibodies As Novel Therapies in Atrial FibrillationR01HL163943 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sami Fouad Noujaim, MICHAEL N TENG · 2023 to 2026
$2.4M
Deciphering the Endothelial Cell-Cardiomyocyte Crosstalk in LMNA CardiomyopathyR01HL158641 · NHLBI · STANFORD UNIVERSITY · PI SAYED, NAZISH · 2021 to 2025
$2.2M
Unraveling the role of endothelium in chemotherapy-induced cardiotoxicityR01HL161002 · NHLBI · STANFORD UNIVERSITY · PI SAYED, NAZISH · 2022 to 2025
$1.6M
Unraveling Proteasome Inhibitor-Induced Cardiovascular Toxicity through Integrative MultiomicsR01HL176822 · NHLBI · STANFORD UNIVERSITY · PI MARK MERCOLA, Joseph C. Wu · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL113006NHLBI NIH HHS R01 HL130020NHLBI NIH HHS R01 HL145676NHLBI NIH HHS R01 HL146690NHLBI NIH HHS R01 HL158641NHLBI NIH HHS R01 HL161002NHLBI NIH HHS R01 HL163680NHLBI NIH HHS R01 HL163943NHLBI NIH HHS R01 HL176822
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

arrhythmogenesisfentanylhERG channelopioid abuseopioid-induced cardiac arrestprolonged repolarization

Identifiers

PMID40854017
PMCPMC12380127

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.