Evidence map›Paper›PMID 40853754›Full record

ArticleThe Journal of physiology2026

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology.

Izzatullo Sobitov, Katharina Ritzenhoff, Marie Gaulrapp, Lea Becker, Aiste Liutkute, Fitzwilliam Seibertz, Funsho E Fakuade, Fleur E Mason, Niels Voigt

Abstract read
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Izzatullo SobitovInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0002-2737-4956
Katharina RitzenhoffInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.
Marie GaulrappInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.ORCID https://orcid.org/0009-0002-9285-4582
Lea BeckerInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.
Aiste LiutkuteInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0002-8855-4870
Fitzwilliam SeibertzInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0002-8554-5186
Funsho E FakuadeInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0001-6683-6079
Fleur E MasonInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.ORCID https://orcid.org/0009-0001-6583-0190
Niels VoigtInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Georg-August University Göttingen, Göttingen, Germany.ORCID https://orcid.org/0000-0001-8230-2341

Funding

Deutsche Forschungsgemeinschaft (DFG) SFB1002projectA13Deutsche Forschungsgemeinschaft (DFG) VO1568/3-1Deutsche Forschungsgemeinschaft (DFG) VO1568/3-2Deutsche Forschungsgemeinschaft (DFG) VO1568/4-1Deutsche Forschungsgemeinschaft (DFG) VO1568/6-1Deutsche Herzstiftung (German Heart Foundation)Deutscher Akademischer Austauschdienst (DAAD)Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81X4300133Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81X4300135Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81X4300136Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81X4300140Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) DZHK 81X4300102Germany's Excellence Strategy EXC 2067/1-390729940
6 · The paper itself

Abstract

Blebbistatin is an excitation-contraction uncoupling agent commonly used in cardiac optical mapping; however, it has been reported to influence cardiac myofilament Ca

Indexed as

CalciumHeterocyclic Compounds, 4 or More RingsMyocytes, CardiacAnimalsCells, CulturedRatsSarcoplasmic ReticulumblebbistatinCalciumHeterocyclic Compounds, 4 or More Ringsblebbistatincalcium bufferingcardiac arrhythmiaexcitation–contraction coupling

Identifiers

PMID40853754
PMCPMC13481002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.