ArticleThe Journal of physiology2025
Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons.
Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Proteoglycan Dynamics and Bone Quality: Molecular Regulation to Age-Related Fragility.Biomolecules · 2026Review
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3 authors.
Funding
Abstract
Tendons are soft musculoskeletal tissues that transfer tensile loads from muscle to bone and consist of a highly organized extracellular matrix. Highly and repetitively loaded tendons such as the Achilles tendon are more susceptible to injury, and injuries are prevalent in the older population. Glycosaminoglycans (GAGs) are long polysaccharide chains that decrease in number with age in tendon and other musculoskeletal tissues. Yet, little is known of the role of GAGs in the tensile mechanics of the ageing Achilles tendon. The objective of this study was to investigate the mechanical role of GAGs in the ageing Achilles tendon. We enzymatically digested GAGs from the Achilles tendons of young, middle-aged and old C57BL/6 mice, removing a total of 64% of GAGs from the tendon insertion and midsubstance. GAG removal did not affect viscoelastic or structural properties across age in the Achilles tendon, paired with no changes to fibril realignment. However, removal of GAGs altered regional material properties at the Achilles tendon insertion in young mice in the absence of any material property changes to the Achilles tendon midsubstance. Finally, we found no changes to regional properties at the Achilles tendon insertion or midsubstance in middle-aged or old mice. In summary, GAG content influences regional mechanical properties at the calcaneal insertion of the Achilles tendon in young mice. KEY POINTS: The Achilles tendon is among the most commonly injured tendons, and aged tendon injuries are becoming an increasingly present societal burden. Glycosaminoglycans decrease across age in the Achilles tendon, yet their effect on structural properties, viscoelasticity and fibre realignment is minimal. In young Achilles tendons, glycosaminoglycans influence the elastic modulus near the calcaneal insertion, which was 60% greater following chondroitinase treatment. These data elucidate the mechanical role of glycosaminoglycans in the healthy Achilles tendon across age.
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