Evidence map›Paper›PMID 40853714›Full record

ArticleChemMedChem2025

Novel Pyrazolo [1,5-a]-1,3,5-Triazine Derivatives as CDK7 Inhibitors: Synthesis and Biological Insights in Pancreatic Ductal Adenocarcinoma Models.

Daniela Carbone, Francesca Terrana, Ludovica Sciuto, Camilla Pecoraro, Geng Xu, Stella Cascioferro, Girolamo Cirrincione, Godefridus J Peters, Elisa Giovannetti, Barbara Parrino and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniela CarboneDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze Ed.16, 90128, Palermo, Italy.
Francesca TerranaDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze Ed.16, 90128, Palermo, Italy.
Ludovica SciutoDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University, 1081 HV, Amsterdam, the Netherlands.
Camilla PecoraroDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze Ed.16, 90128, Palermo, Italy.
Geng XuDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University, 1081 HV, Amsterdam, the Netherlands.
Stella CascioferroDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze Ed.16, 90128, Palermo, Italy.
Girolamo CirrincioneDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze Ed.16, 90128, Palermo, Italy.
Godefridus J PetersDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University, 1081 HV, Amsterdam, the Netherlands.
Elisa GiovannettiDepartment of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University, 1081 HV, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-7565-7504
Barbara ParrinoDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze Ed.16, 90128, Palermo, Italy.ORCID https://orcid.org/0000-0003-0163-1579
Patrizia DianaDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze Ed.16, 90128, Palermo, Italy.

Funding

cod. 202243KSPJ_001CUPDutch Cancer Society, AIRC, and PANOMICPRIN2022 D.D. n. 104STSM
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC), the most prevalent form of pancreatic tumor, is one of the most aggressive and lethal tumor types. Cyclin-dependent kinase 7 (CDK7) has been recently identified as a promising target in multiple human and mouse PDAC preclinical tumor models, due to significant downregulation of gene transcription and preferential inhibition of the mitotic cell cycle. With the aim of finding new CDK7 inhibitors, new indolyl and 7-aza-indolyl pyrazolo [1,5-a]-1,3,5-triazine derivatives are efficiently synthesized and screened for antiproliferative activity against three immortalized cell lines (SUIT 2.28, PATU-T, PANC-1) of PDAC. 8 out of 33 derivatives show remarkable cytotoxicity with IC

Indexed as

Antineoplastic AgentsCarcinoma, Pancreatic DuctalCyclin-Dependent KinasesPancreatic NeoplasmsProtein Kinase InhibitorsPyrazolesTriazinesAnimalsCell Line, TumorCell MovementCell ProliferationCyclin-Dependent Kinase-Activating KinaseDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureAntineoplastic AgentsCDK7 protein, humanCyclin-Dependent Kinase-Activating KinaseCyclin-Dependent KinasesProtein Kinase InhibitorsPyrazolesTriazinesantiproliferative activityCDK7 inhibitioninhibition of cells migrationpancreatic ductal adenocarcinomapyrazolo[1,5‐a]−1,3,5‐triazine derivativesspheroids shrinkage

Identifiers

PMID40853714
PMCPMC12503906

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.