Evidence map›Paper›PMID 40853441›Full record

ArticleOral radiology2026

Efficacy of low-dose rate brachytherapy utilizing a mold with gold-198 grains for hard palate and gingival cancer.

Hitomi Nojima, Atsushi Kaida, Mihoko Haraguchi, Mai Murase, Mariko Hattori, Hirofumi Tomioka, Hiroyuki Harada, Ryoichi Yoshimura, Masahiko Miura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hitomi NojimaDepartment of Dental Radiology and Radiation Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8549, Japan.
Atsushi KaidaDepartment of Dental Radiology and Radiation Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8549, Japan. kai.mdth@tmd.ac.jp.ORCID 0000-0001-5891-4348
Mihoko HaraguchiDepartment of Advanced Prosthodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Mai MuraseDepartment of Advanced Prosthodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Mariko HattoriDepartment of Advanced Prosthodontics, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Hirofumi TomiokaDepartment of Oral and Maxillofacial Surgical Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Hiroyuki HaradaDepartment of Oral and Maxillofacial Surgical Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Ryoichi YoshimuraDepartment of Radiation Therapeutics and Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8549, Japan.
Masahiko MiuraDepartment of Dental Radiology and Radiation Oncology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8549, Japan. masa.mdth@tmd.ac.jp.

Funding

Japan Society for the Promotion of Science 23K27787
6 · The paper itself

Abstract

objectivesMold therapy using gold-198 grains (Au-mold therapy) is a radical treatment for early stage oral cancer owing to its localized delivery of radiation. Understanding the efficacy and limitations of Au-mold therapy is crucial for optimizing treatment protocols and enhancing outcomes. Thus, this study evaluated the treatment outcomes of Au-mold therapy in patients with hard palate and gingival cancer and assessed its feasibility as a therapeutic modality.

methodsThis retrospective study analyzed data from 37 cases with hard palate and gingival cancer who received Au-mold therapy alone. Treatment outcomes and complications were evaluated, and the dose distribution of Au-mold therapy was simulated using clinically available calculation systems.

resultsA notable 5-year local control rate of approximately 80% was noted in primary cases, whereas recurrent cases exhibited lower local control rates. Severe oral mucositis was not observed, and late complications, such as osteoradionecrosis and oral ulceration, were infrequent following Au-mold therapy.

conclusionsThis study provides insights into the use of Au-mold therapy for oral cancer. Promising outcomes in primary cases suggest its potential as a treatment option. Future research should focus on innovative strategies to enhance the efficacy of Au-mold therapy in oral cancer management.

Indexed as

BrachytherapyGingival NeoplasmsGold RadioisotopesPalatal NeoplasmsPalate, HardAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRadiotherapy DosageRetrospective StudiesTreatment OutcomeGold RadioisotopesBrachytherapyDose simulationGold-198 grainMold therapyOral cancer

Identifiers

PMID40853441
PMCPMC12779743

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.