Observational studyJournal of clinical monitoring and computing2025
Relationship between effect site concentration of remimazolam at loss of consciousness and time to extubation: a prospective, single-centre, observational study.
Observational study in Journal of clinical monitoring and computing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical utility of effect-site concentration simulation during remimazolam general anesthesia.Journal of anesthesia · 2026Article
- Effect of flumazenil on recovery of memory following recovery of consciousness from general anesthesia with remimazolam: a randomized, open-label, single-center controlled trial.JA clinical reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calculating the effect site concentration of remimazolam intraoperatively facilitates the prediction of the time from the end of remimazolam administration until the effect site concentration returns to the level at loss of consciousness (LOC). We hypothesised that the effect site concentration of remimazolam at LOC could be an indicator of arousal. This prospective, observational, single-centre study enrolled 107 patients who underwent laparoscopic surgery under remimazolam general anaesthesia. Sedative [bispectral index (BIS®) and SedLine®], non-invasive cardiac output (estimated continuous cardiac output®), and effect site concentration of remimazolam monitoring were assessed simultaneously. The intraoperative remimazolam dose was adjusted to obtain the spectral edge frequency 95 (SEF) < 16 on SedLine®. The primary endpoint was the relationship between the time for the effect site concentration of remimazolam to return to its level at LOC and recovery of consciousness (ROC). The median time from recovery of the effect site concentration of remimazolam to its level at LOC until ROC was 4.0 min. In the multivariate-adjusted general linear model, maintenance administration time and the effect site concentration of remimazolam ratio were significantly associated with the interval between effect site concentration of remimazolam recovery to LOC levels until ROC. This interval was significantly longer in patients whose effect site concentration of remimazolam ratio was lower. The effect site concentration of remimazolam at LOC could be useful for determining arousal time. The effect site concentration ratio and surgery duration could affect the time from recovery of effect site concentration of remimazolam to LOC levels until ROC.
Indexed as
Identifiers
40853426What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.