SynthesisAge and ageing2025
Features of successful medication review and deprescribing interventions for fall prevention in residential aged care facilities: an intervention component analysis of an updated systematic review.
Synthesis in Age and ageing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Drug Utilisation of Fall-Risk-Increasing Drugs (FRIDs) and Risk of Hospitalisation: A Nested Case-Control Study Among Community-Dwelling Older Adults.Drugs & aging · 2026Article
- Implementing a Falls Conversation Package in General Practice: A Service Evaluation.Journal of clinical medicine · 2026Article
- Perceptions of Fall Prevention and Engagement in Social Prescribing Activities Among Older Adults: A Cross-Sectional Study in Portugal.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundMedication review and deprescribing are common fall prevention strategies, as falls risk increasing drugs and polypharmacy are potentially modifiable falls risk factors. We sought to understand why some trials in residential aged care facilities (RACFs) testing medication review/deprescribing reduced falls whilst others did not. We used intervention component analysis (ICA) to develop a theory of the key feature(s) from the trialists' perspective.
methodsRandomised controlled trials (RCTs) evaluating medication review/deprescribing as a single falls prevention intervention in RACFs, were identified via a Cochrane review and additional database searches to 1 April 2025. ICA was conducted with inductive thematic analysis of the Discussion sections of trial publications. Alignment between themes/subthemes and trial outcomes were examined.
resultsThirteen trials from six countries were included. Trialists perceived that medication review/deprescribing interventions should include a tool (i.e. algorithm/list of medications) to facilitate decisions between clinicians on the appropriateness of resident's prescriptions, with at least one prescriber from the residents' usual care team involved in decisions and implementation of medication changes, reviewing medications together at least 6 monthly. These features were present in 100% (3/3) successful trials and 20% (2/10) unsuccessful trials.
conclusionsICA indicated using a tool as a guide amongst clinicians, at least six monthly and including at least one prescriber from the usual care team, could be an important combination of features to improve intervention success. This approach which aligns with recent World Falls Guidelines should be tested in future RCTs of medication optimisation for people living in RACFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.