Evidence map›Paper›PMID 40853000›Full record

ArticlemSphere2025

Proteomic and metabolomic analysis reveals new insights into quaternary amine metabolism in

Roshan Timsina, Ryan A Gora, Donald J Ferguson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roshan TimsinaDepartment of Microbiology, Miami University, Oxford, Ohio, USA.ORCID 0000-0001-5030-2769
Ryan A GoraDepartment of Microbiology, Miami University, Oxford, Ohio, USA.
Donald J FergusonDepartment of Microbiology, Miami University, Oxford, Ohio, USA.ORCID 0000-0002-0595-3033

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Alternative routes of gut microbial methylamine metabolism that may limit trimethylamine N-oxide, a trigger for atherosclerosis.R01DK109345 · NIDDK · OHIO STATE UNIVERSITY · PI KRZYCKI, JOSEPH ADRIAN · 2016 to 2020
$2.2M
NCI NIH HHS P30 CA016058NIDDK NIH HHS R01 DK109345NIH HHS P30 CA016058
6 · The paper itself

Abstract

Gut microbiota and human physiology are closely linked, and our microbiota can influence disease through immunological and metabolic activity. Quaternary amines, such as choline and carnitine, are abundant in the human gut and are found in red meat, beef, eggs, seafood, wheat, and beets. Canonically, choline and carnitine are broken down into the pro-atherogenic metabolite, trimethylamine (TMA), by various microbes in the human gut. A glycyl radical enzyme, CutC, is involved in the breakdown of choline to TMA. Carnitine is broken down to TMA via a gamma-butyrobetaine intermediate. TMA from the human gut increases levels of TMA

Indexed as

CitrobacterMetabolomicsBetaineCarnitineCholineGastrointestinal MicrobiomeHumansMethylaminesProteomicsBetaineCarnitineCholineMethylaminestrimethylamineatherosclerosisCitrobacter amalonaticus CJ25dehydrogenasesnon-atherogenicquaternary amines

Identifiers

PMID40853000
PMCPMC12482172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.