Evidence map›Paper›PMID 40852988›Full record

ArticlemBio2025

AuxB interacts directly with GpsB and PknB to coordinate cell envelope processes that contribute to intrinsic antibiotic resistance in

Tyler A Sisley, Youngseon Park, Ace George Santiago, Wanassa Beroual, Isabella A Sobolewski, Wonsik Lee, Joao A Paulo, Suzanne Walker

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tyler A SisleyDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-7711-6234
Youngseon Park *Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2591-2650
Ace George Santiago *Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2280-6297
Wanassa BeroualDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Isabella A SobolewskiDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0009-0001-8285-7424
Wonsik LeeDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
Suzanne WalkerDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-0545-914X

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI David C Hooper · 2009 to 2026
$39.4M
Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Peptidoglycan Biogenesis in Escherichia ColiR01AI083365 · NIAID · HARVARD MEDICAL SCHOOL · PI Thomas G Bernhardt · 2010 to 2026
$8.3M
Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
Developing proteomics pipelines to improve depth, throughput, and accuracyR35GM156406 · NIGMS · HARVARD MEDICAL SCHOOL · PI Joao A Paulo · 2025 to 2026
$878k
Howard Hughes Medical InstituteNational Science Foundation Graduate Research Fellowship Program DGE1745303NIAID NIH HHS P01 AI083214NIAID NIH HHS R01 AI083365NIAID NIH HHS R01 AI148752NIAID NIH HHS U19 AI158028NIGMS NIH HHS GM132129, GM156406NIGMS NIH HHS R01 GM132129NIGMS NIH HHS R35 GM156406NIH HHS AI083214,AI158028,AI148752NIH HHS AI083365
6 · The paper itself

Abstract

IMPORTANCE:

Indexed as

Bacterial ProteinsCell MembraneCell WallDrug Resistance, BacterialMembrane ProteinsProtein Serine-Threonine KinasesStaphylococcus aureusAnti-Bacterial AgentsProtein BindingTunicamycinAnti-Bacterial AgentsBacterial ProteinsMembrane ProteinsProtein Serine-Threonine KinasesTunicamycinantibiotic resistancecell envelopecell wallPknBserine/threonine kinasesStaphylococcus aureus

Identifiers

PMID40852988
PMCPMC12505970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.