Evidence map›Paper›PMID 40852984›Full record

ArticlemBio2025

Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways.

Yi Miao, Vikas Yadav, William Shadrick, Jiuyu Liu, Alexander R Jenner, Connie B Nichols, Clifford Gee, Martin Schäfer, Jennifer L Tenor, John R Perfect and 3 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yi Miao *Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-0738-6041
Vikas Yadav *Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
William ShadrickDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jiuyu LiuDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Alexander R JennerDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Connie B NicholsDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Clifford GeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Martin SchäferDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.
Jennifer L TenorDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
John R PerfectDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Richard E LeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Richard G BrennanDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7647-485X
Erica J WashingtonDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-7503-6492

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Trehalose Pathway for Antifungal Targets and InhibitorsP01AI104533 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2015 to 2019
$9.0M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
Pathobiology of C. neoformans in the Central Nervous SystemR01AI073896 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 2008 to 2018
$4.4M
Calcineurin signaling cascades governing Cryptococcus virulenceR01AI172451 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2023 to 2026
$2.7M
Coordinated responses to host-derived stresses in C. neoformansR01AI175711 · NIAID · DUKE UNIVERSITY · PI ANDREW ALSPAUGH · 2023 to 2026
$1.5M
NIAID NIH HHS P01 AI104533NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI073896NIAID NIH HHS R01 AI172451NIAID NIH HHS R01 AI175711NIAID NIH HHS R37 AI039115NIGMS NIH HHS P30 GM124169NIH HHS 1P01AI104533NIH HHS A193257NIH HHS AI73896
6 · The paper itself

Abstract

Infections caused by fungal pathogens such as

Indexed as

Antifungal AgentsCandida albicansCryptococcus neoformansEnzyme InhibitorsGlucosyltransferasesThermotoleranceTrehaloseAntifungal AgentsEnzyme InhibitorsGlucosyltransferasesTrehalosetrehalose-6-phosphate synthaseantifungalCandidaCryptococcusTps1trehalose

Identifiers

PMID40852984
PMCPMC12505902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.