Evidence map›Paper›PMID 40852982›Full record

ArticlemBio2025

Genome-wide CRISPRi screen and proteomic profiling identify key genes related to ferulic acid's antifungal activity.

Ofri Levi, Rina Zuchman, Nour Sleman, Roni Koren, Hazem Khamaisi, Benjamin A Horwitz

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ofri LeviFaculty of Sciences and Technology, Tel-Hai Academic College, Upper Galilee, Israel.ORCID 0000-0001-5253-8257
Rina ZuchmanFaculty of Sciences and Technology, Tel-Hai Academic College, Upper Galilee, Israel.
Nour SlemanFaculty of Sciences and Technology, Tel-Hai Academic College, Upper Galilee, Israel.
Roni KorenFaculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Hazem KhamaisiFaculty of Sciences and Technology, Tel-Hai Academic College, Upper Galilee, Israel.
Benjamin A HorwitzFaculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-1558-4497

Funding

Israel Science Foundation ISF 927/22Leona M. and Harry B. Helmsley Charitable Trust The Helmsley Fellowships for Sustainability and Health
6 · The paper itself

Abstract

Fungal pathogens of plants must overcome host-imposed stressors, including antimicrobial small molecules. Ferulic acid (FA), a plant-derived phenolic compound, induces fungal stress and cell death. To uncover genetic determinants of FA sensitivity, we performed a genome-wide CRISPR interference (CRISPRi) screen in

Indexed as

Antifungal AgentsCoumaric AcidsSaccharomyces cerevisiaeAscomycotaCandida albicansClustered Regularly Interspaced Short Palindromic RepeatsDrug Resistance, FungalErgosterolMicrobial Sensitivity TestsProteomicsAntifungal AgentsCoumaric AcidsErgosterolferulic acidantifungal resistanceCRISPR interference (CRISPRi)drug synergyeco-friendly fungicidesergosterol biosynthesisferulic acidfungal pathogensplant-derived phenolic compounds

Identifiers

PMID40852982
PMCPMC12505964

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.