Evidence map›Paper›PMID 40852931›Full record

Observational studyCNS neuroscience & therapeutics2025

Assessment of Dysphagia in Chinese Cohort of Angelman Syndrome: An Observational Study.

Yumeng Chen, Yanna Wang, Yi Zhang, Jun Wang, Xiaonan Du, Tianqi Wang, Yi Wang, Hao Zhou

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yumeng ChenDepartment of Rehabilitation, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yanna WangDepartment of Rehabilitation, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yi ZhangDepartment of Clinical Epidemiology and Clinical Trial Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Jun WangDepartment of Rehabilitation, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Xiaonan DuDepartment of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Tianqi WangDepartment of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Yi WangDepartment of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Hao ZhouDepartment of Rehabilitation, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Funding

Clinical-Basic Dual Pairing Initiative of the Children's Hospital of Fudan University EKSJD202424National Natural Science Foundation of China 82302103Qingmiao Program of the Children's Hospital of Fudan University EKQM202440the Shanghai Municipal Science and Technology Major Project Phase II 2023SHZDZX02C08
6 · The paper itself

Abstract

aimsThis study aims to identify the prevalence and risk factors of dysphagia in a Chinese cohort of Angelman syndrome (AS).

methodsA structured questionnaire was used to assess the status of patients in a Chinese cohort of AS. Swallowing function was evaluated using the Pediatric Eating Assessment Tool-10, with gastrointestinal symptoms quantified via the Six-item Gastrointestinal Severity Index (6-GSI). To identify potential risk factors, univariable and multivariate logistic regression was performed.

resultsAmong 490 patients with AS (median 6 years, interquartile range 4 years), the molecular subtypes of 75.7% of cases were deletions of 15q11-q13. The prevalence of dysphagia reached 56.1%. Patients with dysphagia exhibited lower BMI values compared to nondysphagia cases (15.31 ± 2.87 vs. 15.92 ± 2.91 kg/m

conclusionsOver half of Chinese patients with AS experience dysphagia, with UPD moderating risk and comorbidities amplifying susceptibility.

Indexed as

Angelman SyndromeDeglutition DisordersAdolescentChildChild, PreschoolChinaCohort StudiesEast Asian PeopleFemaleHumansMalePrevalenceRisk FactorsAngelman syndromedysphagiagastrointestinal symptomrisk factorswallowing function

Identifiers

PMID40852931
PMCPMC12376064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.