Evidence map›Paper›PMID 40852870›Full record

ArticleProtein science : a publication of the Protein Society2025

Inhibitor-induced dimerization mediates lufotrelvir resistance in mutants of SARS-CoV-2 3C-like protease.

Guanyu Wang, Felipe Venegas, Andres Rueda, Osvaldo Yañez, Manuel I Osorio, Sibei Qin, José Manuel Pérez-Donoso, Christopher J Thibodeaux, Nicolas Moitessier, Anthony K Mittermaier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guanyu WangDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-6792-3091
Felipe VenegasDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.
Andres RuedaDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.
Osvaldo YañezCentro de Modelación Ambiental y Dinámica de Sistemas (CEMADIS), Facultad de Ingeniería y Negocios, Universidad de Las Américas, Santiago, Chile.ORCID 0000-0001-8993-9353
Manuel I OsorioFacultad de Odontología, Universidad Andres Bello, Santiago, Chile.ORCID 0000-0002-1297-8351
Sibei QinDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.ORCID 0009-0009-6035-0196
José Manuel Pérez-DonosoBioNanotechnology and Microbiology Laboratory, Center for Bioinformatics and Integrative Biology (CBIB), Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.ORCID 0000-0002-9506-1716
Christopher J ThibodeauxDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-4792-8362
Nicolas MoitessierDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-6933-2079
Anthony K MittermaierDepartment of Chemistry, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-3767-1225

Funding

CIHR MOP-13694CIHR OV3-170644Natural Sciences and Engineering Research Council of Canada 327028-09
6 · The paper itself

Abstract

The emergence of SARS-CoV-2 and other lethal coronaviruses has prompted extensive research into targeted antiviral treatments, particularly focusing on the viral 3C-like protease (3CL

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesDrug Resistance, ViralSARS-CoV-2HumansMutationProtein Multimerization3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C Proteases3CLproallosteric couplingcoronavirusdrug resistanceligand‐induced dimerizationSARS‐CoV‐2

Identifiers

PMID40852870
PMCPMC12375981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.