Evidence map›Paper›PMID 40852827›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

De-Saturation of Single-Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions.

Qilong Cai, Yang Meng, Chao Wu, Wenjia Qu, Qiang Wang, Tan Li, Chengyi Liu, Jinxing Chen, Huihui Lin, Qian He and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qilong CaiDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.ORCID https://orcid.org/0000-0003-3932-702X
Yang MengDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Chao WuCollege of Materials Science and Engineering, Sichuan University, Chengdu, 610065, P. R. China.
Wenjia QuDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Qiang WangDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Tan LiDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Chengyi LiuInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road Jurong Island, Singapore, 627833, Singapore.
Jinxing ChenDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Huihui LinDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Qian HeDepartment of Materials Science and Engineering, National University of Singapore, Singapore, 117574, Singapore.
Yafei ZhaoDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Shibo XiInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road Jurong Island, Singapore, 627833, Singapore.
Jiong LuDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.ORCID https://orcid.org/0000-0002-3690-8235

Funding

Agency for Science, Technology and Research Project ID M22K2c0082Competitive Research Program Award MOE-T2EP10123-0004Competitive Research Program Award MOE-T2EP10221-0005Competitive Research Program Award MOE-T2EP10223-0004Competitive Research Program Award NRF-CRP29-2022-0004Science and Technology Project of Jiangsu Province BZ2022056SUSTech-NUS joint research program A-8002269-00-00SUSTech-NUS joint research program A-8002269-01-00SUSTech-NUS joint research program A-8002269-02-00
6 · The paper itself

Abstract

Rational design of proximal coordination microenvironments surrounding catalytic sites to achieve optimal reaction kinetics represents a paramount pursuit in single-atom catalysts (SACs), yet continues to pose substantial synthetic challenges. Developing innovative strategies that simultaneously stabilize low-coordinated single-metal species on solid supports, while ensuring atomic precision and high activity, remains imperative. Herein, a de-saturation strategy for SACs is demonstrated (denoted as De-sat SACs) using a top-down approach based on a KOH-mediated Joule thermal shock to obtain under-coordinated and asymmetric SACs for efficient organic synthesis. Using copper-based SACs as a proof-of-concept, the de-saturation strategy effectively converts the CuN

Indexed as

de‐saturation strategyKOH‐mediated Joule thermalpropargylic substitution reactionssingle‐atom catalysts

Identifiers

PMID40852827
PMCPMC12710579

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.