Evidence map›Paper›PMID 40852784›Full record

ArticleAngewandte Chemie (International ed. in English)2025

A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection.

Atsuya Yaguchi, Noriyuki Uchida, Daiki Miura, Go Watanabe, Hirotsugu Hiramatsu, Itsuki Ajioka, Teruhiko Matsubara, Toshinori Sato, Chinbat Enkhzaya, Shunto Itani and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Atsuya YaguchiDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.
Noriyuki UchidaDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.
Daiki MiuraDepartment of Physics, School of Science, Kitasato University, 1-15-1 Kitasato, Sagamihara, Minami-ku, 252-0373, Japan.
Go WatanabeDepartment of Physics, School of Science, Kitasato University, 1-15-1 Kitasato, Sagamihara, Minami-ku, 252-0373, Japan.
Hirotsugu HiramatsuDepartment of Applied Chemistry and Institute of Molecular Science, National Yang Ming Chiao Tung University, 1001 Ta-Hsueh Road, Hsinchu, 30010, Taiwan.
Itsuki AjiokaProject of Regenerative Medicine for Stroke using Supramolecular Peptide Kanagawa Institute of Industrial Science and Technology (KISTEC), 3-2-1 Sakato, Takatsu-ku, Kawasaki, Kanagawa, 213-0012, Japan.
Teruhiko MatsubaraDepartment of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, 223-8522, Japan.
Toshinori SatoDepartment of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, 223-8522, Japan.
Chinbat EnkhzayaDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.
Shunto ItaniDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.
Tomokazu SaitoDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.
Takahiro MuraokaDepartment of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan.ORCID 0000-0001-6744-048X

Funding

ACT-X JPMJAX23DLAdvanced Research Infrastructure for Materials and Nanotechnology in Japan JPMXP1224UT0073Asahi Glass FoundationCanon FoundationCore Research for Evolutional Science and Technology JPMJCR19S4Fusion Oriented Research for Disruptive Science and Technology JPMJFR2122Grant-in-Aid for Transformative Research Areas (B) JP21H05096Japan Association for Chemical InnovationJapan Society for the Promotion of ScienceKose Cosmetology FoundationLotte FoundationNew Energy and Industrial Technology Development Organization 23W1M041Tanaka FoundationToyota Riken FoundationUrakami Foundation for Food and Food Culture Promotion
6 · The paper itself

Abstract

Viruses are versatile colloidal materials in their biofunctions, monodispersed and periodic structures, and high surface designability. For expanding the applicability of virus-based materials, spatiotemporally controlled immobilization and dispersion of viruses with retained activity should be useful, though control of the dynamic nature of viruses hybridized with commonly used polymers has been difficult due to their strong interactions. Here, we report a self-assembling peptide (A2Az) enabling photo control of adhesion and dispersion of M13 bacteriophage virus (M13 phage) and successfully demonstrate patterning of localization and infection of the virus. A2Az is a cationic peptide with amphiphilicity that consists of eight amino acid residues containing a photo-responsive azobenzene group at the second position and self-assembles into a helical supramolecular fiber to form a hydrogel. The helical fibrillar morphology of A2Az exhibits strong interaction with M13 phage, allowing for immobilization not only on a two-dimensional surface but also in a three-dimensional hydrogel with suppression of infectivity. The A2Az fiber undergoes a light-triggered fiber-to-particle transition and releases the immobilized M13 phage with retained infectivity for the photo-controlled patterning of localization and infection. This approach has potential applicability to various virus-based biomaterials, such as structural materials and materials for photo-selective gene transfection to cells.

Indexed as

Bacteriophage M13PeptidesHydrogelsLightPhotochemical ProcessesHydrogelsPeptidesGelsPeptidesPolymersSupramolecular chemistryViruses

Identifiers

PMID40852784
PMCPMC12501715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.