ArticleFrontiers in immunology2025
Meta-analysis of multi-center transcriptomic profiles and machine learning reveal phospholipase Cβ4 as a Wnt/Ca²
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Genome-Wide Characterization of the wnt Gene Family Reveals aAnimals : an open access journal from MDPI · 2026Article
- Recent applications of artificial intelligence in cancer radiotherapy and immunotherapy: current status and future directions.Frontiers in immunology · 2026Review
- Artificial Intelligence-Driven Multi-Omics Approaches in Glioblastoma.International journal of molecular sciences · 2025Review
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Authors and funding
11 authors.
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Abstract
Introduction: Glioblastoma (GBM) is a highly aggressive brain tumor characterized by pronounced invasiveness, rapid progression, frequent recurrence, and poor clinical prognosis. Current treatment strategies remain inadequate due to the lack of effective molecular targets, underscoring the urgent need to identify novel therapeutic avenues. Methods: In this study, we employed weighted gene co-expression network analysis and meta-analysis, incorporating clinical immunotherapy datasets, to identify ten candidate genes associated with GBM initiation, progression, prognosis, and response to immunotherapy. Multi-omics analyses across glioma and pan-cancer datasets revealed that these genes play pivotal roles in cancer biology. Results: Phospholipase Cb4 (PLCB4) showed a negative correlation with tumor grade in clinical samples, suggesting its potential role as a tumor suppressor. Evidence indicated that PLCB4 expression is modulated by Wnt signaling, and its overexpression may activate the calcium ion signaling pathway. Notably, Discussion: This study's integrative approach-combining target identification, pathway inference, and in silico drug screening-offers a promising framework for rational drug development in GBM. The findings may reduce unnecessary experimental screening and medical costs, and represent a significant step toward improving therapeutic outcomes and prognosis for GBM patients.
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