Evidence map›Paper›PMID 40852712›Full record

ArticleFrontiers in immunology2025

Distinct humoral responses induced by heterologous versus homologous prime-boost immunization strategies in early life.

Poorya Foroutan Pajoohian, Audur Anna Aradottir Pind, Jenny Lorena Molina Estupiñan, Dennis Christensen, Gabriel Kristian Pedersen, Thorunn A Olafsdottir, Ingileif Jonsdottir, Stefania P Bjarnarson

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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Poorya Foroutan PajoohianFaculty of Medicine, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Audur Anna Aradottir PindFaculty of Medicine, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Jenny Lorena Molina EstupiñanFaculty of Medicine, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Dennis ChristensenCenter for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
Gabriel Kristian PedersenCenter for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
Thorunn A OlafsdottirFaculty of Medicine, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Ingileif JonsdottirFaculty of Medicine, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Stefania P BjarnarsonFaculty of Medicine, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An important component in the development of efficacious vaccines is the optimization of vaccination schedules to elicit protective immunity, especially in a vulnerable group like infants. Mucosal IgA plays an important role in the initial defense at mucosal surfaces, protecting against the colonization of respiratory pathogens, potentially reducing invasion and disease severity, while systemic immunity relies on protective IgG antibodies (Abs). This study aims to design an immunization strategy inducing both optimal systemic and mucosal immune responses using heterologous prime-boost immunization in comparison to homologous immunization. We immunized neonatal mice with a pneumococcal conjugate vaccine, Pn1-CRM

Indexed as

Immunity, HumoralImmunization, SecondaryPneumococcal VaccinesAdjuvants, ImmunologicAdministration, IntranasalAnimalsAnimals, NewbornAntibodies, BacterialFemaleImmunity, MucosalImmunizationImmunoglobulin AImmunoglobulin GMiceMice, Inbred BALB CVaccinationAdjuvants, ImmunologicAntibodies, BacterialImmunoglobulin AImmunoglobulin GPneumococcal Vaccinesantibody levelsantibody-secreting cellsheterologous immunization routesmucosal immunityneonatal vaccination

Identifiers

PMID40852712
PMCPMC12367788

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.