ReviewIndian journal of orthopaedics2025
Bio-Active Composite Therapy (BACT) in Regenerative Orthopaedics.
Review in Indian journal of orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Bio-Active Composite Therapy (BACT) represents a significant advancement in regenerative orthopaedics, integrating bioactive materials with biological systems to enhance bone and tissue regeneration. This comprehensive approach leverages materials such as hydroxyapatite, bioactive glasses, polymers, and metals to create scaffolds that mimic the extracellular matrix, facilitating cellular activities essential for tissue repair. Methods: A systematic literature review was conducted using databases including PubMed, Scopus, Web of Science, and Google Scholar. Keywords such as "Bio-Active Composite Therapy," "regenerative orthopaedics," and "bioactive materials" were employed to identify relevant studies published between 2000 and 2024. Inclusion criteria focused on peer-reviewed articles, reviews, and clinical trials related to the development, application, and evaluation of BACT in bone and soft tissue regeneration. Data extraction emphasized bioactive material types, fabrication techniques, clinical applications, outcomes, and associated challenges. The findings were categorized thematically to synthesize current advancements and identify knowledge gaps. Results: BACT utilizes a diverse range of bioactive materials, with hydroxyapatite and bioactive glasses being predominant due to their osteoconductive and osteoinductive properties. Advanced fabrication techniques, particularly additive manufacturing (e.g., 3D printing), enable the creation of scaffolds with precise geometries and tailored porosity, enhancing cellular adhesion and proliferation. Clinically, BACT has demonstrated efficacy in bone regeneration, cartilage repair, and ligament healing, although biocompatibility and immunotoxicity remain challenges, especially with certain metal oxides like TiO₂. Economic barriers and technical precision in scaffold application also pose significant limitations. Conclusion: BACT holds transformative potential in regenerative orthopaedics by offering tailored, effective treatments for musculoskeletal disorders. Overcoming biocompatibility, safety, and accessibility challenges through interdisciplinary collaboration and technological innovation is essential for its widespread clinical adoption. Future research should focus on optimizing bioactive materials and fabrication methods, alongside rigorous clinical trials to validate long-term efficacy and safety. Graphical Abstract:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.