ArticleFrontiers in neurology2025
Surgical treatment of myasthenia gravis: 10 years of single center experience.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Objective: To evaluate a 10-year experience in the surgical treatment of patients with myasthenia gravis, focusing on clinical and pharmacological outcomes. Methods: A retrospective single-center study was conducted based on prospective data collection from the Redcap® maintained by the Thoracic Surgery Department in a Brazilian tertiary hospital. Patients with myasthenia gravis (AchR positive), who underwent surgical treatment as an adjuvant to clinical therapy were included. Results: The study comprised 85 patients with a mean age of 43 years; 75% were female. Regarding the type of surgery, 24.7% underwent sternotomy and 75.3% minimally invasive approach. The median hospital stay was 4.0 days (p25 = 3.0; p75 = 5.5), and the median ICU stay was 1.0 days (p25 = 0.40, p75 = 2). Postoperative outcomes showed a corticosteroid reduction in 52 participants (61%), and 30 (35%) showed anticholinesterase reduction. The median dose of corticosteroids before surgery was 40.00 mg, and after surgery, 20.00 ( Conclusion: This study demonstrated that surgical treatment for myasthenia gravis is safe and effective for symptom control and medication reduction, regardless of the surgical approach, with shorter ICU and hospital stays through the minimally invasive approach.
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