ArticleFrontiers in oncology2025
Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative parameters.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A Retrospective Study on Predicting Ki-67 Expression in Esophageal Cancer Patients Based on Delta Radiomics.Journal of imaging · 2026Article
- Dual-energy CT-based nomogram for predicting progression-free survival in locally advanced nasopharyngeal carcinoma.Frontiers in oncology · 2025Article
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Authors and funding
6 authors.
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Abstract
Aim: This study investigates the use of dual-energy computed tomography (DECT) quantitative parameters to assess Ki-67 expression levels in esophageal squamous cell carcinoma (ESCC). Methods: A total of 57 ESCC patients who underwent dual-phase DECT scans were included. Key parameters measured were iodine concentration (IC), water concentration (WC), normalized iodine concentration (NIC), spectral Hounsfield unit curve slope (λHu), and effective atomic number (Zeff). Univariate and multivariate analyses identified factors associated with Ki-67 expression levels. Results: Results showed that high Ki-67 expression correlated with significantly higher Zeff and IC values in the venous phase (VP) (P = 0.047 and P = 0.049, respectively; AUC = 0.67 for both), and lower WC in the arterial phase (AP) (P = 0.021; AUC = 0.70). Multivariate analysis revealed that IC in VP and WC in AP were independent predictors of Ki-67 overexpression. The combination of these two parameters yielded an AUC of 0.78 for predicting Ki-67 overexpression, with 68.3% sensitivity, 87.5% specificity, and 73.7% accuracy. Conclusions: DECT parameters demonstrate potential for non-invasive Ki-67 status detection in ESCC, offering valuable insights for clinical diagnosis and prognosis.
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