Evidence map›Paper›PMID 40852474›Full record

ArticleInternational journal of cardiology. Heart & vasculature2025

Sex differences in hospitalisation and healthcare utilisation for patients with atrial fibrillation

Melissa E Middeldorp, Colinda van Deutekom, Liann I Weil, Isabelle C Van Gelder, Ursula W De Ruijter, Patrick T Jeurissen, Emelia J Benjamin, Barbara C van Munster, Michiel Rienstra

Abstract read
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melissa E MiddeldorpDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Colinda van DeutekomDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Liann I WeilUniversity of Groningen, University Medical Center Groningen, Department of Geriatric Medicine, Groningen, the Netherlands.
Isabelle C Van GelderDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ursula W De RuijterErasmus University Medical Center, Department of Public Health, Rotterdam, the Netherlands.
Patrick T JeurissenRadboud University Medical Center, Radboud Institute for Health Sciences, Scientific Center for Quality of Healthcare (IQ Healthcare), Nijmegen, the Netherlands.
Emelia J BenjaminDepartment of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, United States of America.
Barbara C van MunsterUniversity of Groningen, University Medical Center Groningen, Department of Geriatric Medicine, Groningen, the Netherlands.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is limited data on sex differences in healthcare utilization among patients with atrial fibrillation (AF). This study aimed to assess the association of sex and age on healthcare utilization in AF patients. Methods: We conducted a retrospective analysis of electronic health records from three hospitals in the Netherlands, including all patients ≥ 18 years with at least one healthcare encounter (outpatient, emergency visit, or inpatient stay). AF diagnoses were identified using ICD-10 codes linked with the Dutch Hospital Data Clinical Classification Software. Results: Of 226,991 patients, 5127 (2.3 %) had AF (44 % females, mean age 68 ± 12 years). There were no sex differences in outpatient, emergency, or inpatient visits overall. However, females aged 18-59 had more outpatient visits compared to males (6.1 ± 7.9 vs 4.8 ± 5.2, p = 0.001). In contrast, females aged ≥ 75 had fewer outpatient visits (7.2 vs 8.4, p < 0.001) and inpatient days (4.8 vs 5.8, p = 0.027) compared to males. After multivariable adjustment, both sexes aged ≥ 75 had increased risks of inpatient stays (Females: OR 2.53, 95 % CI 2.30-2.78; Males: OR 1.49, 95 % CI 1.46-1.62) and emergency visits (Females: OR 2.14, 95 % CI 1.94-2.35; Males: OR 1.13, 95 % CI 1.03-1.24). Significant interactions between sex and age were found, with females having higher odds of inpatient days (OR 1.99, p < 0.001) and emergency visits (OR 1.23, p < 0.001) compared to males. Conclusion: While no overall sex differences in healthcare utilization were found, significant age-related differences were observed, with females having higher hospital utilization rates, particularly for inpatient stays and emergency visits.

Indexed as

AgeAtrial fibrillationHealthcare utilisationSex

Identifiers

PMID40852474
PMCPMC12369424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.