ReviewAesthetic surgery journal. Open forum2025
A Systematic Review of Adipose-Derived Cell Therapies on Skin Quality.
Review in Aesthetic surgery journal. Open forum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Combined and Layered Fat Injection for Lower Eyelid Wrinkles: Comparative Efficacy in Mild and Severe Cases.Aesthetic plastic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin aging leads to changes such as dyschromia, rhytids, dermal atrophy, and reduced elasticity. Adipose-derived cell therapies (ADCTs), including stromal vascular fraction (SVF), adipose-derived stem cells (ADSCs), and adipose-derived mesenchymal stem cells (AD-MSCs), have gained attention for their regenerative potential. In this systematic review, the authors aim to evaluate the effectiveness of ADCT in improving skin quality such as elasticity, texture, pigmentation, and rhytid reduction. This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, with a comprehensive search conducted across PubMed (National Library of Medicine, Bethesda, MD), Embase (Elsevier, Amsterdam, the Netherlands), and Scopus (Elsevier). The authors of eligible studies must have assessed skin quality outcomes, such as rhytids, dyschromia, texture, and elasticity. Data on study design, treatment protocols, and outcomes were extracted. Risk of bias was assessed using the Cochrane RoB 2 tool (Cochrane, London, United Kingdom). Meta-analyses were conducted where appropriate. Seventeen studies met inclusion criteria. Rhytid severity decreased with SVF and ADSC-conditioned medium, particularly in periorbital and nasolabial regions. However, the authors of a meta-analysis of 2 studies showed nonsignificant reduction in rhytids (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.