ArticleFrontiers in veterinary science2025
Preparation and pharmacokinetic study of mebendazole complex with HP-beta-cyclodextrin.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mebendazole, approved by the Food and Drug Administration (FDA) in 1974 to expel intestinal parasite infections, was found to exhibit multiple anti-cancer activities. However, due to its poor water solubility (0.33 ± 0.02 μg/mL), its clinical applications were greatly limited. Scientists at Wenzhou-Kean University have developed a formulation that could increase its water solubility as much as 18,333 times to reach 6.05 mg/mL as the best result to date. Through the complexation with HP-beta-cyclodextrin, 80% of mebendazole in the complex was released
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