Evidence map›Paper›PMID 40852424›Full record

ArticlePNAS nexus2025

Global survey of secondary metabolism in

Cameron Semper, Thi Thanh My Pham, Shane Ram, Sylvester Palys, Gregory Evdokias, Jean-Paul Ouedraogo, Marie-Claude Moisan, Nicholas Geoffrion, Ian Reid, Marcos Di Falco and 4 more

Abstract read
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cameron SemperDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, T2N 4N1, Canada.ORCID https://orcid.org/0000-0003-2025-799X
Thi Thanh My PhamCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.
Shane RamDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, T2N 4N1, Canada.ORCID https://orcid.org/0000-0001-5407-2286
Sylvester PalysCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.
Gregory EvdokiasCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.
Jean-Paul OuedraogoCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.
Marie-Claude MoisanCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.
Nicholas GeoffrionCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.
Ian ReidCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.
Marcos Di FalcoCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.
Zachary BaileyDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, T2N 4N1, Canada.
Adrian TsangCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.ORCID https://orcid.org/0000-0002-5892-4797
Isabelle Benoit-GelberCentre for Structural and Functional Genomics, Concordia University, 7141 Rue Sherbrooke Ouest, Montreal, Quebec, H4B 1R6, Canada.ORCID https://orcid.org/0000-0002-7168-9496
Alexei SavchenkoDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, T2N 4N1, Canada.ORCID https://orcid.org/0000-0002-5256-9237

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomics analysis confirmed the status of filamentous fungi as a rich source of novel secondary metabolites; however, the discovery of these compounds is hampered by the cryptic nature of their biosynthetic pathways under laboratory conditions. Consequently, despite substantial research effort over the past decades, much of the secondary metabolome remains uncharacterized in fungal organisms. Our manual curation of biosynthetic gene clusters (BGCs) in the

Indexed as

natural productssecondary metabolismtranscriptional regulation

Identifiers

PMID40852424
PMCPMC12368960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.