Evidence map›Paper›PMID 40852405›Full record

ArticleJournal of scleroderma and related disorders2025

Treatment recommendations for the systemic pharmacological treatment of systemic sclerosis digital ulcers: Results from the World Scleroderma Foundation Ad Hoc Committee.

Nancy Maltez, Laura Ross, Murray Baron, Alessia Alunno, Corrado Campochiaro, Yossra A Suliman, Jan W Schoones, Yannick Allanore, Francesco Del Galdo, Christopher P Denton and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of scleroderma and related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Nancy MaltezDivision of Rheumatology, Department of Medicine, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-8535-4312
Laura RossDepartment of Medicine and Rheumatology, University of Melbourne at St Vincent's Hospital, Melbourne, VIC, Australia.
Murray BaronDivision of Rheumatology, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Alessia AlunnoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Corrado CampochiaroDepartment of Immunology, Rheumatology, Allergy and Rare Diseases, Raffaele Hospital, Vita-Salute San Raffaele Universita, Milan, Italy.ORCID https://orcid.org/0000-0001-6806-3794
Yossra A SulimanDepartment of Rheumatology and Rehabilitation, Assiut University Hospital, Assiut, Egypt.ORCID https://orcid.org/0000-0003-2919-1966
Jan W SchoonesDirectorate of Research Policy (formerly Walaeus Library), Leiden University Medical Center, Leiden, The Netherlands.
Yannick AllanoreDepartment of Rheumatology, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France.
Francesco Del GaldoLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.ORCID https://orcid.org/0000-0002-8528-2283
Christopher P DentonCentre for Rheumatology and Connective Tissue Diseases, Royal Free Hospital, London, UK.ORCID https://orcid.org/0000-0003-3975-8938
Oliver DistlerDepartment of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-0546-8310
Tracy FrechDivision of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Veterans Affairs Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-5472-3840
Daniel E FurstDepartment of Rheumatology and Medicine, University of California, Los Angeles, CA, USA.
Dilia GiuggioliDivision of Rheumatology, Department of Rheumatology, University of Modena and Reggio Emilia, Policlinico of Modena, Modena, Italy.ORCID https://orcid.org/0000-0002-0041-3695
Dinesh KhannaDepartment of Rheumatology, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0001-6822-3401
Thomas KriegDivision of Rheumatology, Department of Rheumatology, University of Modena and Reggio Emilia, Policlinico of Modena, Modena, Italy.
Masataka KuwanaDepartment of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8352-6136
Marco Matucci-CerinicDivision of Rheumatology, Department of Experimental and Clinical Medicine, Careggi University Hospital, University of Florence, Florence, Italy.
Pia MoinzadehDepartment of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
Janet PopeSchulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.ORCID https://orcid.org/0000-0003-1479-5302
Lorinda ChungDepartment of Rheumatology, Stanford University School of Medicine and Palo Alto VA Health Care System, Palo Alto, CA, USA.
Michael HughesDepartment of Rheumatology, Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Salford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Digital ulcers are an important disease manifestation of systemic sclerosis and are associated with significant morbidity. As such, there is an urgent need for the development of evidence-based recommendations to guide clinicians in the treatment of digital ulcers. Methods: A steering committee of international experts was established. A systematic review of the literature pertaining to the use of pharmacologic treatments in the management of digital ulcers was performed to inform the development of treatment recommendations for systemic sclerosis digital ulcers. Consensus methodology was used to develop the final treatment recommendations. Results: The World Scleroderma Foundation committee agreed on 8 overarching treatment principles and 10 pharmacologic treatment recommendations for the management of systemic sclerosis digital ulcers. Phosphodiesterase 5 inhibitors and intravenous iloprost were recommended for the management of acute digital ulcers. Bosentan was recommended for prevention of digital ulcers. Conclusion: This study has yielded pragmatic treatment recommendations to direct treatment decisions for the management of systemic sclerosis digital ulcers. In addition, results have highlighted areas in need of future research in order to improve patient outcomes.

Indexed as

consensusdigital ulcerrecommendationsSystemic sclerosistreatment

Identifiers

PMID40852405
PMCPMC12367710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.