ArticleFrontiers in medicine2025
Assessing the impact of liver fat fraction on portal hemodynamics in nonalcoholic fatty liver disease using MRI proton density fat fraction and MRI 4D Flow.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Correlation analysis and diagnostic performance of CT/MRI fat quantification parameters in metabolic dysfunction-associated steatotic liver disease.Frontiers in medicine · 2026Article
- Portal vein hemodynamics measured by 4D flow MRI in predicting minimal hepatic encephalopathy in chronic hepatic schistosomiasis patients.Frontiers in medicine · 2025Article
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Authors and funding
5 authors.
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Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition with significant implications for liver and cardiovascular health. Alterations in portal hemodynamics due to hepatic steatosis remain poorly understood. Aim: This study aims to explore the correlation between liver fat fraction (FF) and portal hemodynamics in NAFLD patients. Methods: A retrospective observational study was conducted involving 125 clinical suspected NAFLD patients. Liver FF was measured using MRI proton density fat fraction (PDFF). MRI 4D Flow was used to assess portal hemodynamic parameters, including flow velocity, flow volume, and portal area. Statistical analyses examined the relationships between liver FF and hemodynamic parameters. Results: Liver FF was negatively associated with portal peak flow velocity ( Conclusion: Liver FF is a significant determinant of portal hemodynamics in NAFLD patients. These findings underscore the potential of integrating liver FF and portal hemodynamic assessments into clinical practice for detection and management of NAFLD progression.
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