Evidence map›Paper›PMID 40852209›Full record

ArticleACS catalysis2022

Pd-Catalyzed Chemoselective O‑Benzylation of Ambident 2‑Quinolinone Nucleophiles.

Melissa Cadena, Roberto Silva Villatoro, Jyoti Shah Gupta, Cody Phillips, Jonathan B Allen, Hadi D Arman, Daniel J Wherritt, Nicholas A Clanton, Alexander L Ruchelman, Eric M Simmons and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Synthesis ofACS omega · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Melissa CadenaThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Roberto Silva VillatoroThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Jyoti Shah GuptaThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Cody PhillipsThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Jonathan B AllenThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Hadi D ArmanThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.
Daniel J WherrittThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID 0000-0002-8616-9864
Nicholas A ClantonThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID 0000-0001-5936-4878
Alexander L RuchelmanChemical Process Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States.
Eric M SimmonsChemical Process Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States.ORCID 0000-0002-3854-1561
Albert J DelMonteChemical Process Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States.ORCID 0000-0003-0645-3169
John R CoombsChemical Process Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States.ORCID 0000-0003-1473-2651
Doug E FrantzThe Max and Minnie Tomerlin Voelcker Laboratory for Organic Chemistry, Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID 0000-0002-4509-4579

Funding

UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
NIGMS NIH HHS R25 GM060655
6 · The paper itself

Abstract

We have discovered and developed a highly chemoselective O-benzylation of ambident 2-quinolinone nucleophiles via Pd-catalysis. Detailed reaction analysis using direct-injection high resolution mass spectrometry (DI-HRMS) combined with in situ

Indexed as

2-quinolinonesambident nucleophilescatalytic alkylationchemoselectivityPd-catalysis

Identifiers

PMID40852209
PMCPMC12369975

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.