Evidence map›Paper›PMID 40852192›Full record

ArticleEuropean heart journal open2025

Echocardiographic risk stratification in light chain and transthyretin amyloidosis: a meta-analysis.

David Koeckerling, Rohin K Reddy, Christian Eichhorn, Volker Braun, Yousif Ahmad, James P Howard, Fabian Aus dem Siepen, Benjamin Meder, Norbert Frey, Derliz Mereles

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David KoeckerlingDepartment of Cardiology, Angiology and Pulmonology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.ORCID https://orcid.org/0000-0002-8475-2861
Rohin K ReddyNational Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK.
Christian EichhornHarvard T.H. Chan School of Public Health, Huntington Avenue, Boston, MA 02115, USA.
Volker BraunMedical Faculty Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse, 68167 Mannheim, Germany.
Yousif AhmadDivision of Cardiology, University of California, Parnassus Avenue, San Francisco, CA 94143, USA.
James P HowardNational Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK.
Fabian Aus dem SiepenDepartment of Cardiology, Angiology and Pulmonology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Benjamin MederDepartment of Cardiology, Angiology and Pulmonology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.ORCID https://orcid.org/0000-0003-0741-2633
Norbert FreyDepartment of Cardiology, Angiology and Pulmonology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Derliz MerelesDepartment of Cardiology, Angiology and Pulmonology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: The role of echocardiography in amyloidosis prognostication remains undefined in international guidelines. This meta-analysis aims to evaluate associations between echocardiography-derived measurements and clinical outcomes in light chain (AL) and transthyretin (ATTR) amyloidosis. Methods and results: MEDLINE, Embase, Cochrane Library, and Google Scholar were systematically searched through July 2024 for studies reporting associations between echocardiographic variables [left ventricular global longitudinal strain (LV-GLS), LV ejection fraction (LVEF), tricuspid annular plane systolic excursion (TAPSE), interventricular septum diameter (IVSd), LV mass index (LVMi) and Conclusion: Echocardiographic measures of biventricular deformation, systolic and diastolic function, were consistently associated with mortality in amyloidosis, while structural parameters were not. Echocardiography may have an important role in the initial risk stratification of cardiac amyloidosis.

Indexed as

AmyloidosisCardiomyopathyEchocardiographyLight chainTransthyretin

Identifiers

PMID40852192
PMCPMC12370300

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.