ArticleMalaysian orthopaedic journal2025
Radiographical Assessment of Injectable Calcium Phosphate Bone Cement (Osteopaste) in Critical Size Bone Defects of Rabbit's Tibia Model.
Article in Malaysian orthopaedic journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Recent advances in orthopaedic research focus on improving bone healing and grafting. Osteopaste, a synthetic bone cement made from tetra-calcium phosphate (TTCP) and tri-calcium phosphate (TCP) has been developed to overcome limitations of traditional bone grafts. This study evaluates the radiographic density and new bone formation to bridge the critical size defect of Osteopaste compared to two other synthetic grafts, JectOS (calcium phosphate) and MIIG-X3 (calcium sulfate) at 6, 12, and 24 weeks. Materials and Methods: A critical size defect measuring approximately 4.5mm (width) x 9.0mm (length) was surgically created at the proximal tibial metaphysis and implanted with Osteopaste, JectOS, or MIIG-X3. Following cement implantation, surrounding soft tissues were repositioned and sutured with bioabsorbable surgical suture. Bone defect healing and cement density were qualitatively and quantitatively evaluated using plain radiographs and computed tomography (CT) scans at 6, 12, and 24 weeks. Results: The Osteopaste group showed radiographic density levels between those of JectOS and MIIG-X3. JectOS had the highest density, while Osteopaste was higher than MIIG-X3. In the Osteopaste group, new bone formation bridged the critical size defect by 12 weeks, but no bridging occurred in the other two groups at any time point. Statistical analysis showed significant differences in mean density among the groups at 6, 12, and 24 weeks (P<0.0001). Conclusion: Osteopaste effectively promotes new bone formation. Its performance falls between that of JectOS, which has the highest density, and MIIG-X3. These results suggest that Osteopaste could be a useful alternative for bone grafting.
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