Evidence map›Paper›PMID 40851998›Full record

ArticleAnnals of medicine and surgery (2012)2025

Reactivation of cereberal tuberculosis post-adalimumab therapy for rheumatoid arthritis: a case report.

Adnan Alghazzawi, Zyad Al-Frejat, Marie Ahmad, Fadi Barkil, Lora Shammas, Enas Abood Darwish

Abstract readCase Reports
In one paragraph

Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adnan AlghazzawiDepartment of Neurology, Damascus university, Syria, Damascus, Syria.
Zyad Al-FrejatDepartment of Neurology, Damascus university, Syria, Damascus, Syria.ORCID https://orcid.org/0000-0002-3885-6803
Marie AhmadDepartment of Neurology, Damascus university, Syria, Damascus, Syria.
Fadi BarkilDepartment of Neurology, Damascus university, Syria, Damascus, Syria.
Lora ShammasDepartment of Neurology, Damascus university, Syria, Damascus, Syria.
Enas Abood DarwishDepartment of Neurology, Damascus university, Syria, Damascus, Syria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction and importance: Patients with rheumatoid arthritis who are treated with adalimumab have an increased risk of developing latent infections. The lethal risk of TB encephalitis as a potential manifestation after treatment with adalimumab should not be overlooked despite its rarity. Case presentation: We report a case of a 19-year-old Middle Eastern female who developed cerebral tuberculosis after receiving adalimumab therapy for rheumatoid arthritis. The patient was systemically well. Her medical history included pneumonia, PCOs (polycystic ovary syndrome), and Clinical disscusion: Rheumatoid arthritis patients who are treated with DMARDs are at risk of developing opportunistic infections. While most opportunistic infections are well understood and have clear symptoms, the rare occurrence of encephalitis should not be dismissed. Conclusion: Although rare, TB encephalitis should be considered in patients developing neurological symptoms after treatment with Adalimumab.

Indexed as

adalimumab (anti-TNF)cerebral tuberculomarheumatoid arthritis

Identifiers

PMID40851998
PMCPMC12369760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.