ReviewAnnals of medicine and surgery (2012)2025
Clinical efficacy and mechanistic insights of Xuebijing in hand, foot, and mouth disease: a meta-analysis with integrated pharmacological approaches.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
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Abstract
Background: Hand, foot, and mouth disease (HFMD) is a viral infection, primarily caused by gastrointestinal viruses. Xuebijing (XBJ) injection, widely used in China for treating inflammatory conditions like sepsis, may offer therapeutic benefits for HFMD. This study aimed to evaluate the efficacy and safety of adjunctive XBJ therapy for HFMD. Materials and methods: Databases were systematically searched until February 2024. Meta-analysis used random or fixed-effect models, with outcomes reported as standardized mean differences (SMD) or relative risks (RR) and 95% confidence intervals (CI). Heterogeneity was assessed via Cochran's Results: Six randomized controlled trials (RCTs) involving 786 participants were included. XBJ significantly improved the total effective rate (RR = 1.19, Conclusions: XBJ as adjunctive therapy improves outcomes in HFMD and is safe, with specific molecular targets identified for its therapeutic effects.
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