Evidence map›Paper›PMID 40851918›Full record

ArticleContact in context2024

Potential Process Control Issues With Abatacept.

James T Isaacs, Philip J Almeter, Aaron N Hunter, Thomas A Lyman, Stephanie P Zapata, Bradley S Henderson, Seth A Larkin, Lindsey M Long, Megan N Bossle, Smaran A Bhaktawara and 10 more

Abstract read
In one paragraph

Article in Contact in context, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

James T IsaacsDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Philip J AlmeterDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Aaron N HunterDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Thomas A LymanDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Stephanie P ZapataDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Bradley S HendersonDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Seth A LarkinDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Lindsey M LongDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Megan N BossleDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Smaran A BhaktawaraDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Matthew F WarrenDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Austin M LozierDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Joshua D MelsonDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Savannah R FraleyDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Eunice Hazzel L RelucioDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Margaret A FelixDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Jeffrey W ReynoldsDepartment of Finance, University of Kentucky Healthcare, Lexington, KY.
Ryan W NasemanDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Thomas L PlattDepartment of Pharmacy Services, University of Kentucky Healthcare, Lexington, KY 40536.
Robert A LodderDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536.ORCID 0000-0001-6133-7561

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
NCATS NIH HHS UL1 TR001998
6 · The paper itself

Abstract

Abatacept is a medication administered through intravenous infusion. It is supplied as a sterile, white, preservative-free, freeze-dried powder. Each vial of drug contains 250 mg abatacept, maltose, monobasic sodium phosphate, and sodium chloride for administration. Abatacept is a fusion protein consisting of the extracellular domain of CTLA-4 linked to the modified Fc portion of human immunoglobulin G1. It is produced using recombinant DNA technology. Abatacept is indicated for moderately to severely active rheumatoid arthritis in adults and polyarticular juvenile idiopathic arthritis in pediatric patients 6 years of age and older. It can be used as monotherapy or in combination with other disease-modifying antirheumatic drugs or methotrexate. Inter-lot variability was detected in a library of 132 vials spread across 34 lots of abatacept-maltose for injection by the University of Kentucky Drug Quality Task Force. A subcluster detection test was run on 13 vials that were shown to be an outlier group (r

Identifiers

PMID40851918
PMCPMC12370286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.