Mechanisms of AGE-induced VSMC phenotypic switching and macrophage modulation in human abdominal aortic aneurysms.

Xiaoying Ma, Jinfang Xu, Huiying Sun, Jiajun Liu, Shibo Xia, Hao Zhang, Chaoyi Cui, Chao Song

Abstract read

In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Molecular and spatial heterogeneity of macrophage like vascular smooth muscle cells in abdominal aortic aneurysms associated with intraluminal thrombus.Scientific reports · 2026
Article
Aortic dissection as a disease of vascular wall homeostasis: integrating vasa vasorum-inflammation-metabolism axis for mechanistic insight and clinical translation.Frontiers in immunology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoying Ma *Department of Vascular Surgery, Changhai Hospital, Shanghai, China.

Jinfang Xu *Department of Health Statistics, Naval Medical University, Shanghai, China.

Huiying Sun *Department of Vascular Surgery, Changhai Hospital, Shanghai, China.

Jiajun LiuSchool of Pharmacy, East China University of Science and Technology, Shanghai, China.

Shibo XiaDepartment of Vascular Surgery, Changhai Hospital, Shanghai, China.

Hao ZhangDepartment of Vascular Surgery, Changhai Hospital, Shanghai, China.

Chaoyi CuiDepartment of Vascular Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Chao SongDepartment of Vascular Surgery, Changhai Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced glycation end products (AGEs) have been associated with vascular pathologies including abdominal aortic aneurysms (AAAs), although their causal role remains unclear. In this study, we observed significant accumulation of AGEs in human AAAs, particularly in cases associated with intraluminal thrombus (ILT).

Indexed as

Aortic Aneurysm, AbdominalGlycation End Products, AdvancedMacrophagesMuscle, Smooth, VascularMyocytes, Smooth MuscleAgedCell MovementHumansMaleMiddle AgedPhenotypeSignal TransductionGlycation End Products, Advancedabdominal aortic aneurysmsAGE-RAGEmacrophagesNLRP3VSMC phenotypic switch

Identifiers

PMID40851915

DOI10.3389/ebm.2025.10527

PMCPMC12367564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.